KIF20A在多种癌症中的表达、调控机制及治疗靶点
Expression, regulating mechanism and therapeutic target of KIF20A in multiple cancer.
作者信息
Jin Zheng, Peng Fei, Zhang Chao, Tao Shuang, Xu Damo, Zhu Zhenhua
机构信息
Department of Respirology & Allergy, The Third Affiliated Hospital of Shenzhen University, Shenzhen, Guangdong Province, China.
Department of Medicine, Division of Endocrinology, Diabetes and Metabolism, Baylor College of Medicine, Houston, Texas, USA.
出版信息
Heliyon. 2023 Jan 25;9(2):e13195. doi: 10.1016/j.heliyon.2023.e13195. eCollection 2023 Feb.
Kinesin family member 20A (KIF20A) is a member of the kinesin family. It transports chromosomes during mitosis, plays a key role in cell division. Recently, studies proved that KIF20A was highly expressed in cancer. High expression of KIF20A was correlated with poor overall survival (OS). In this review, we summarized all the cancer that highly expressed KIF20A, described the role of KIF20A in cancer. We also organized phase I and phase II clinical trials of KIF20A peptides vaccine. All results indicated that KIF20A was a promising therapeutic target for multiple cancer.
驱动蛋白家族成员20A（KIF20A）是驱动蛋白家族的一员。它在有丝分裂期间运输染色体，在细胞分裂中起关键作用。最近，研究证明KIF20A在癌症中高表达。KIF20A的高表达与较差的总生存期（OS）相关。在本综述中，我们总结了所有高表达KIF20A的癌症，描述了KIF20A在癌症中的作用。我们还整理了KIF20A肽疫苗的I期和II期临床试验。所有结果表明，KIF20A是多种癌症有前景的治疗靶点。
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