Li Ran, Yang Fei, Zhang Liying, Li Mengzhen, Wang Guo, Wang Weizhi, Xu Yanqing, Wei Wei
Beijing Key Laboratory for Optical Materials and Photonic Devices, Department of Chemistry, Capital Normal University, Beijing, 100048, P. R. China.
Key Laboratory of Medical Molecule Science and Pharmaceutical Engineering, Ministry of Industry and Information Technology, School of Chemistry and Chemical Engineering, Beijing Institute of Technology, Beijing, 100081, P. R. China.
Angew Chem Int Ed Engl. 2023 Apr 17;62(17):e202301267. doi: 10.1002/anie.202301267. Epub 2023 Mar 15.
Water-soluble small organic photothermal agents (PTAs) over NIR-II biowindow (1000-1350 nm) are highly desirable, but the rarity greatly limits their applications. Based on a water-soluble double-cavity cyclophane GBox-4 , we report a class of host-guest charge transfer (CT) complexes as structurally uniform PTAs for NIR-II photothermal therapy. As a result of its high electron-deficiency, GBox-4 can bind different electron-rich planar guests with a 1 : 2 host/guest stoichiometry to readily tune the CT absorption band that extends to the NIR-II region. When using a diaminofluorene guest substituted with an oligoethylene glycol chain, the host-guest system realized both good biocompatibility and enhanced photothermal conversion at 1064 nm, and was then exploited as a high-efficiency NIR-II PTA for cancer cell and bacterial ablation. This work broadens the potential applications of host-guest cyclophane systems and provides a new access to bio-friendly NIR-II photoabsorbers with well-defined structures.
在近红外二区生物窗口（1000 - 1350 nm）内的水溶性小分子有机光热剂（PTA）极具吸引力，但这类物质的稀缺性极大地限制了它们的应用。基于水溶性双腔环芳GBox - 4，我们报道了一类主客体电荷转移（CT）配合物，作为用于近红外二区光热治疗的结构均一的光热剂。由于其高度缺电子，GBox - 4能以1 : 2的主客体化学计量比结合不同的富电子平面客体，从而轻松调节延伸至近红外二区的电荷转移吸收带。当使用带有低聚乙二醇链取代的二氨基芴客体时，该主客体体系在1064 nm处实现了良好的生物相容性和增强的光热转换，进而被用作高效的近红外二区光热剂用于癌细胞和细菌消融。这项工作拓宽了主客体环芳体系的潜在应用，并为具有明确结构的生物友好型近红外二区光吸收剂提供了新途径。
