Institute for Hygiene and Applied Immunology, Center for Pathophysiology, Infectiology, Immunology, Medical University of Vienna, Vienna, Austria.
Institute of Applied Physics, TU Wien, Vienna, Austria.
EMBO J. 2023 Apr 3;42(7):e113507. doi: 10.15252/embj.2023113507. Epub 2023 Feb 20.
T-cell antigen recognition is invariably affected by tensile forces as they are exerted on T-cell antigen receptors (TCRs) transiently binding antigenic peptide/MHC complexes. In this issue of The EMBO Journal, Pettmann and colleagues promote the concept that forces reduce the lifetime of more stable stimulatory TCR-pMHC interactions to a larger extent than that of less stable non-stimulatory TCR-pMHC interactions. The authors argue that forces impede rather than boost T-cell antigen discrimination, which is promoted by force-shielding within the immunological synapse through cell adhesion via CD2/CD58 and LFA-1/ICAM-1.
T 细胞抗原识别总是受到张力的影响，因为它们作用于 T 细胞抗原受体（TCR），使其短暂结合抗原肽/MHC 复合物。在本期《欧洲分子生物学组织杂志》中，Pettmann 及其同事提出了这样一种观点，即力会降低更稳定的刺激 TCR-pMHC 相互作用的寿命，而不是降低不太稳定的非刺激 TCR-pMHC 相互作用的寿命。作者认为，力阻碍了而不是促进了 T 细胞抗原的识别，这种识别是通过免疫突触中的细胞黏附（通过 CD2/CD58 和 LFA-1/ICAM-1）产生的力屏蔽来促进的。
