Zaccone Vincenzo, Santoro Luca, Guerrieri Emanuele, Diblasi Ilaria, Roncarati Ilaria, Viticchi Giovanna, Vecchiarelli Pietro, Santoliquido Angelo, Fiore Francesca, Molfino Alessio, Landi Francesco, Moroncini Gianluca, Gasbarrini Antonio, Muscaritoli Maurizio, Falsetti Lorenzo
Internal and Emergency Medicine, Marche University Hospital, Ancona, Italy.
Department of Cardiovascular and Thoracic Sciences, Fondazione Policlinico Universitario Agostino Gemelli IRCCS, Rome, Italy.
Front Nutr. 2023 Feb 6;10:1106327. doi: 10.3389/fnut.2023.1106327. eCollection 2023.
The implementation of long-term parenteral nutrition (PN) often requires the placement of central venous access, a procedure that carries a considerable risk of catheter-related venous thrombosis (CRT). The occurrence of CRT represents a major event in the natural history of patients in PN since it can lead to central venous access loss and PN failure. Despite the importance of this topic in clinical nutrition, the prevention and treatment of CRT in PN represents one of the "gray areas" of the literature of the presence of few randomized controlled clinical trials and the generally low level of evidence of published scientific papers. Through a narrative review of the literature and a Delphi consensus, the Italian Society of Clinical Nutrition and Metabolism (SINuC) aimed to collect some practical recommendations regarding the current state-of-the-art in the prevention, diagnosis, and treatment of CRT in patients undergoing long-term PN.
长期肠外营养（PN）的实施通常需要放置中心静脉通路，这一操作存在相当大的导管相关静脉血栓形成（CRT）风险。CRT的发生是PN患者自然病程中的一个重大事件，因为它可能导致中心静脉通路丧失和PN失败。尽管这个话题在临床营养中很重要，但PN中CRT的预防和治疗是文献中的“灰色地带”之一，因为随机对照临床试验很少，且已发表科学论文的证据水平普遍较低。通过对文献的叙述性综述和德尔菲共识，意大利临床营养与代谢学会（SINuC）旨在收集一些关于长期PN患者CRT预防、诊断和治疗的当前最新技术的实用建议。
