Obata I, Koike K, Morimoto O, Hachiya S, Yamato T, Hayashi S, Hayashi M
Department of Obstetrics and Gynecology, Jikei University School of Medicine.
Jpn J Antibiot. 1987 Jul;40(7):1259-74.
Ceftriaxone (CTRX) was studied regarding its penetration into the adnexa uteri and uterine tissues, as well as its utility and safety in the treatment of patients with obstetric and gynecologic infections. The results obtained are summarized below. 1. When 1 g of CTRX was administered by intravenous bolus injection, Cmax in tissues of adnexa uteri and uterus ranged from 42.2 to 80.5 micrograms/g, Tmax ranged from 0.42 to 0.81 hour, and the AUC ranged from 314.9 to 606.9 micrograms.hr/g. Thus, drug penetration into these tissues was good. 2. Clinical efficacy of CTRX was evaluated in 29 obstetric and gynecological patients. The clinical efficacy was good in all cases. 3. Bacteriological effects of CTRX were very good, and 90% of the organisms isolated before treatment were eradicated. 4. Laboratory testing revealed an occurrence of mild eosinophilia in 1 case.
对头孢曲松（CTRX）进行了研究，观察其在子宫附件和子宫组织中的渗透情况，以及在治疗妇产科感染患者中的效用和安全性。获得的结果总结如下。1. 通过静脉推注给药1 g CTRX时，子宫附件和子宫组织中的Cmax范围为42.2至80.5微克/克，Tmax范围为0.42至0.81小时，AUC范围为314.9至606.9微克·小时/克。因此，药物在这些组织中的渗透良好。2. 对29例妇产科患者评估了CTRX的临床疗效。所有病例的临床疗效均良好。3. CTRX的细菌学效果非常好，治疗前分离出的90%的病原体被根除。4. 实验室检测发现1例出现轻度嗜酸性粒细胞增多。
