Hirabayashi K, Okada E
Jpn J Antibiot. 1984 Dec;37(12):2384-90.
Ceftriaxone (Ro13-9904, CTRX), a newly developed cephalosporin antibiotic, was fundamentally evaluated through determination of the levels in the female genital organ tissues and in the pelvic dead space exudate. CTRX was also studied on its clinical efficacy in 13 cases with gyneco-obstetric infections. The transmission of CTRX into the female genital organ tissues was favorable: the peak level in each tissue was as high as 38 to 63 micrograms/g 18 to 37 minutes after administration. The level in each tissue even after about 18 hours remained around 10 micrograms/g, suggesting its better transmission into the tissues than other drugs. The transmission into the pelvic dead space exudate was also good: the level reached a peak of 100 to 120 micrograms/ml 1 to 3 hours after administration and still ranged from 74 to 76 micrograms/ml even after about 12 hours. The clinical efficacy was excellent in 5, good in 5 and poor in 3 out of 13 cases with gyneco-obstetric infections and the efficacy rate was 76.9%. Neither adverse reaction nor laboratory test abnormality was observed in any case. The above-mentioned results suggest that CTRX is a useful antibiotic for gyneco-obstetric infections.
头孢曲松（Ro13 - 9904，CTRX）是一种新开发的头孢菌素抗生素，通过测定其在女性生殖器官组织和盆腔死腔渗出液中的含量进行了基础评估。还对13例妇产科感染患者进行了CTRX临床疗效研究。CTRX向女性生殖器官组织的传递情况良好：给药后18至37分钟，各组织中的峰值水平高达38至63微克/克。即使在约18小时后，各组织中的水平仍保持在10微克/克左右，表明其向组织中的传递比其他药物更好。其向盆腔死腔渗出液中的传递也良好：给药后1至3小时，水平达到峰值100至120微克/毫升，即使在约12小时后仍在74至76微克/毫升范围内。在13例妇产科感染病例中，5例临床疗效极佳，5例良好，3例较差，有效率为76.9%。所有病例均未观察到不良反应或实验室检查异常。上述结果表明，CTRX是一种用于妇产科感染的有效抗生素。
