Yamamoto T, Yasuda J, Kanao M, Okada H
Jpn J Antibiot. 1984 Dec;37(12):2355-63.
Fundamental and clinical studies on ceftriaxone (CTRX, Ro 13-9904), a new cephalosporin antibiotic, were carried out with the following results. Concentration of CTRX was examined in serum, internal genital organs and retroperitoneal fluid after single intravenous administration of 1.0 g dose. The venous serum level of CTRX was 156 micrograms/ml at 5 minutes after the administration. The favorable transfer of CTRX to internal genital organs and retroperitoneal fluid was demonstrated. In clinical trial, CTRX was given to 10 cases with obstetrical and gynecological infections such as endometritis, adnexitis, pelvic peritonitis and parametritis. The efficacy was evaluated as excellent in 1 case, good in 8 cases and poor in 1 case. No side effects were observed in any of the cases treated with CTRX.
对新型头孢菌素抗生素头孢曲松（CTRX，Ro 13 - 9904）进行了基础和临床研究，结果如下。单次静脉注射1.0 g剂量后，检测了血清、内生殖器和腹膜后液中CTRX的浓度。给药后5分钟时，静脉血清中CTRX水平为156微克/毫升。结果表明CTRX能良好地转移至内生殖器和腹膜后液。在临床试验中，对10例患有诸如子宫内膜炎、附件炎、盆腔腹膜炎和子宫旁组织炎等妇产科感染的患者给予了CTRX。疗效评估为1例优，8例良，1例差。接受CTRX治疗的所有病例均未观察到副作用。
