Laflamme Olivier D, Markin Sergey N, Banks Rachel, Zhang Ying, Danner Simon M, Akay Turgay
Atlantic Mobility Action Project, Brain Repair Centre, Department of Medical Neuroscience, Dalhousie University, Halifax, Nova Scotia, Canada.
Department of Neurobiology and Anatomy, College of Medicine, Drexel University, Philadelphia, Pennsylvania, United States of America.
bioRxiv. 2023 Feb 18:2023.02.16.528842. doi: 10.1101/2023.02.16.528842.
Crossed reflexes (CR) are mediated by commissural pathways transmitting sensory information to the contralateral side of the body, but the underlying network is not fully understood. Commissural pathways coordinating the activities of spinal locomotor circuits during locomotion have been characterized in mice, but their relationship to CR is unknown. We show the involvement of two genetically distinct groups of commissural interneurons (CINs) described in mice, V0 and V3 CINs, in the CR pathways. Our data suggest that the exclusively excitatory V3 CINs are directly involved in the excitatory CR, and show that they are essential for the inhibitory CR. In contrast, the V0 CINs, a population that includes excitatory and inhibitory CINs, are not directly involved in excitatory or inhibitory CRs but down-regulate the inhibitory CR. Our data provide insights into the spinal circuitry underlying CR in mice, describing the roles of V0 and V3 CINs in CR.
交叉反射（CR）由连合通路介导，该通路将感觉信息传递至身体的对侧，但其中潜在的神经网络尚未完全明确。在小鼠中，已对在运动过程中协调脊髓运动回路活动的连合通路进行了表征，但其与交叉反射的关系尚不清楚。我们发现小鼠中描述的两组基因不同的连合中间神经元（CIN），即V0和V3 CIN，参与了交叉反射通路。我们的数据表明，仅具有兴奋性的V3 CIN直接参与兴奋性交叉反射，并表明它们对抑制性交叉反射至关重要。相比之下，V0 CIN群体包括兴奋性和抑制性CIN，它们不直接参与兴奋性或抑制性交叉反射，但会下调抑制性交叉反射。我们的数据为小鼠交叉反射背后的脊髓神经回路提供了见解，描述了V0和V3 CIN在交叉反射中的作用。
