Atlantic Mobility Action Project, Brain Repair Centre, Department of Medical Neuroscience, Dalhousie University, Halifax, NS B3T 0A6, Canada.
Department of Neurobiology and Anatomy, College of Medicine, Drexel University, Philadelphia, PA 19129, USA.
Curr Biol. 2023 Aug 21;33(16):3452-3464.e4. doi: 10.1016/j.cub.2023.07.014. Epub 2023 Aug 1.
Crossed reflexes are mediated by commissural pathways transmitting sensory information to the contralateral side of the body, but the underlying network is not fully understood. Commissural pathways coordinating the activities of spinal locomotor circuits during locomotion have been characterized in mice, but their relationship to crossed reflexes is unknown. We show the involvement of two genetically distinct groups of commissural interneurons (CINs) described in mice, V0 and V3 CINs, in the crossed reflex pathways. Our data suggest that the exclusively excitatory V3 CINs are directly involved in the excitatory crossed reflexes and show that they are essential for the inhibitory crossed reflexes. In contrast, the V0 CINs, a population that includes excitatory and inhibitory CINs, are not directly involved in excitatory or inhibitory crossed reflexes but downregulate the inhibitory crossed reflexes. Our data provide insights into the spinal circuitry underlying crossed reflexes in mice, describing the roles of V0 and V3 CINs in crossed reflexes.
交叉反射是由联络通路介导的，这些通路将感觉信息传递到身体的对侧，但基础网络尚未完全理解。在运动过程中协调脊髓运动回路活动的联络通路已在小鼠中得到描述，但它们与交叉反射的关系尚不清楚。我们显示了在小鼠中描述的两个具有遗传差异的联络中间神经元 (CIN) 群体，即 V0 和 V3 CIN，参与了交叉反射途径。我们的数据表明，兴奋性的 V3 CIN 直接参与兴奋性交叉反射，并表明它们对抑制性交叉反射是必不可少的。相比之下，V0 CIN 是一个包括兴奋性和抑制性 CIN 的群体，它不直接参与兴奋性或抑制性交叉反射，但下调抑制性交叉反射。我们的数据为小鼠交叉反射的脊髓回路提供了深入了解，描述了 V0 和 V3 CIN 在交叉反射中的作用。
