Monto A S, Gunn R A, Bandyk M G, King C L
JAMA. 1979 Mar 9;241(10):1003-7.
We tested the effectiveness of amantadine hydrochloride in prevention of illness and infection caused by Russian (h1n1) influenza. The trial lasted seven weeks and was double-blind and placebo controlled. The dosage used was 200 mg daily. Efficacy in prevention of serologically confirmed clinical influenza was 70.7%. Efficacy in prevention of infection, symptomatic or asymptomatic, was 39.4%. Side effects seen were all mild, began within two days of the start of the trial, and terminated rapidly on cessation of prophylaxis. The withdrawal rate attributable to use of amantadine was 6.2%. Those who continued to receive prophylaxis for the remainder of the trial did not exhibit excess side effects. It is concluded that amantadine is safe and effective in prophylaxis of H1N1 strains, as has been shown previously for other subtypes of A influenza.
我们测试了盐酸金刚烷胺预防俄罗斯（H1N1）流感所致疾病和感染的效果。试验持续了七周，采用双盲、安慰剂对照。所用剂量为每日200毫克。预防血清学确诊的临床流感的有效率为70.7%。预防有症状或无症状感染的有效率为39.4%。观察到的副作用均较轻微，在试验开始后两天内出现，并在停止预防后迅速消失。因使用金刚烷胺导致的退出率为6.2%。在试验剩余时间继续接受预防的患者未出现额外的副作用。结论是，如先前对甲型流感其他亚型所显示的那样，金刚烷胺在预防H1N1毒株方面是安全有效的。
