Carreón González José Luis, García Casillas Perla Elvia, Chapa González Christian
Grupo de Nanomedicina, Instituto de Ingenieria y Tecnología, Universidad Autónoma de Ciudad Juárez, Avenida del Charro 450, Ciudad Juárez 32310, Mexico.
Centro de Investigación en Química Aplicada (CIQA), Blvd. Enrique Reyna Hermosillo 140, Saltillo 25294, Mexico.
Micromachines (Basel). 2023 Feb 15;14(2):451. doi: 10.3390/mi14020451.
The use of gold nanoparticles as drug delivery systems has received increasing attention due to their unique properties, such as their high stability and biocompatibility. However, gold nanoparticles have a high affinity for proteins, which can result in their rapid clearance from the body and limited drug loading capabilities. To address these limitations, we coated the gold nanoparticles with silica and PEG, which are known to improve the stability of nanoparticles. The synthesis of the nanoparticles was carried out using a reduction method. The nanoparticles' size, morphology, and drug loading capacity were also studied. The SEM images showed a spherical and homogeneous morphology; they also showed that the coatings increased the average size of the nanoparticles. The results of this study provide insight into the potential of gold nanoparticles coated with silica and PEG as drug delivery systems. We used ibuprofen as a model drug and found that the highest drug load occurred in PEG-coated nanoparticles and then in silica-coated nanoparticles, while the uncoated nanoparticles had a lower drug loading capacity. The coatings were found to significantly improve the stability and drug load properties of the nanoparticles, making them promising candidates for further development as targeted and controlled release drug delivery systems.
由于金纳米颗粒具有诸如高稳定性和生物相容性等独特性质，其作为药物递送系统的应用受到了越来越多的关注。然而，金纳米颗粒对蛋白质具有高亲和力，这可能导致它们从体内快速清除以及药物负载能力有限。为了解决这些局限性，我们用二氧化硅和聚乙二醇包覆金纳米颗粒，已知这两种物质可提高纳米颗粒的稳定性。纳米颗粒的合成采用还原法进行。还研究了纳米颗粒的尺寸、形态和药物负载能力。扫描电子显微镜图像显示出球形且均匀的形态；这些图像还表明包覆层增加了纳米颗粒的平均尺寸。本研究结果为包覆有二氧化硅和聚乙二醇的金纳米颗粒作为药物递送系统的潜力提供了见解。我们使用布洛芬作为模型药物，发现最高的药物负载量出现在聚乙二醇包覆的纳米颗粒中，其次是二氧化硅包覆的纳米颗粒，而未包覆的纳米颗粒药物负载能力较低。结果发现包覆层显著改善了纳米颗粒的稳定性和药物负载性质，使其成为有前景的进一步开发为靶向和控释药物递送系统的候选材料。
