Jacobs S C, Nelson J C, Zisook S
Yale University, New Haven, Connecticut.
Psychiatr Clin North Am. 1987 Sep;10(3):501-10.
Seven of 10 bereaved, depressed spouses had moderate to marked improvement of depressive symptoms during a 4-week open trial of tricyclic antidepressants. Several considerations suggested that this was a response in large part to the pharmacologic intervention and not simply to a therapeutic relationship. The application of antidepressants to treatment of the persistent major depressive syndromes observed late in the course of bereavement should be studied in systematic, controlled studies with larger samples. This is an important clinical issue given the high risk of prolonged depressive syndromes in acutely bereaved spouses.
在一项为期4周的三环类抗抑郁药开放试验中，10名丧偶且抑郁的配偶中有7名的抑郁症状得到了中度至显著改善。有几个因素表明，这在很大程度上是对药物干预的反应，而不仅仅是对治疗关系的反应。抗抑郁药在丧亲之痛后期观察到的持续性重度抑郁综合征治疗中的应用，应在更大样本的系统对照研究中进行探讨。鉴于急性丧偶配偶中出现长期抑郁综合征的风险很高，这是一个重要的临床问题。
