Brega Carlotta, Albertini Alberto
Department of Cardiovascular Surgery, GVM Care and Research, Cotignola, RA, Italy.
Aorta (Stamford). 2023 Feb;11(1):29-35. doi: 10.1055/s-0042-1757949. Epub 2023 Feb 27.
Nowadays, despite the rapid advancements in interventional cardiology, open surgery still deals with aortic root diseases, to assure the best "ad hoc" treatment. In case of middle-aged adult patients, the optimal operation still represents a matter of debate. A review of the last 10-year literature was conducted, focusing on patients below 65 to 70 years of age. Because of the small sample and the heterogeneity of the papers, no metanalysis was possible. Bentall-de Bono procedure, valve sparing, and Ross operations are the surgical options currently available. The main issues in the Bentall - de Bono operation are lifelong anticoagulation therapy and cavitation in case of mechanical prosthesis implantation and structural valve degeneration in case of biological Bentall. As transcatheter procedures are currently performed as valve in valve, biological prosthesis may be preferable, if the diameter may prevent postoperative high gradients. Conservative techniques, such as remodeling and reimplantation, preferred in the young, guarantee physiologic aortic root dynamics and impose surgical analysis of the aortic root structures to get a durable result. The Ross operation, which shows excellent performance, involves autologous pulmonary valve implantation and is performed only in experienced and high-volume centers. Due to its technical difficulty, it requires a steep learning curve and presents some limitations in specific aortic valve diseases. All three have advantages and downsides, and no ideal solution has still been reported.
如今,尽管介入心脏病学发展迅速,但对于主动脉根部疾病,开放手术仍是确保最佳“临时”治疗的手段。对于中年成年患者,最佳手术方案仍存在争议。我们对过去10年的文献进行了回顾,重点关注65至70岁以下的患者。由于样本量小且文献存在异质性,无法进行荟萃分析。Bentall - de Bono手术、保留瓣膜手术和Ross手术是目前可用的手术选择。Bentall - de Bono手术的主要问题包括终身抗凝治疗、植入机械瓣膜时的空化现象以及植入生物瓣膜时的结构瓣膜退变。由于目前经导管手术是作为瓣中瓣进行的,如果直径可防止术后出现高梯度,生物瓣膜可能更可取。保守技术,如重塑和再植入,在年轻患者中更受青睐,可保证主动脉根部的生理动力学,并要求对主动脉根部结构进行手术分析以获得持久效果。表现出色的Ross手术涉及自体肺动脉瓣植入,仅在经验丰富且手术量大的中心进行。由于其技术难度大,需要陡峭的学习曲线,并且在特定主动脉瓣疾病中存在一些局限性。这三种手术都有优缺点,目前仍未报道有理想的解决方案。