School of Pharmacy, Faculty of Medicine and Health, University of Sydney, Sydney, NSW 2006, Australia.
Pharmacy Department, Campbelltown Hospital, Campbelltown, NSW 2560, Australia.
Int J Pharm. 2023 Mar 25;635:122785. doi: 10.1016/j.ijpharm.2023.122785. Epub 2023 Feb 26.
The current healthcare dynamic has shifted from one-size-fits-all to patient-centred care, with our increased understanding of pharmacokinetics and pharmacogenomics demanding a switch to more individualised therapies. As the pharmaceutical industry remains yet to succumb to the push of a technological paradigm shift, pharmacists lack the means to provide completely personalised medicine (PM) to their patients in a safe, affordable, and widely accessible manner. As additive manufacturing technology has already established its strength in producing pharmaceutical formulations, it is necessary to next consider methods by which this technology can create PM accessible from pharmacies. In this article, we reviewed the limitations of current pharmaceutical manufacturing methods for PMs, three-dimensional (3D) printing techniques that are most beneficial for PMs, implications of bringing this technology into pharmacy practice, and implications for policy surrounding 3D printing techniques in the manufacturing of PMs.
当前的医疗保健模式已经从一刀切转变为以患者为中心的护理，我们对药代动力学和药物基因组学的理解不断加深，这要求我们转向更加个体化的治疗方法。由于制药行业尚未屈服于技术范式转变的推动，药剂师缺乏以安全、负担得起且广泛可及的方式为患者提供完全个体化药物 (PM) 的手段。由于增材制造技术已经在生产药物制剂方面确立了其优势，因此有必要考虑如何利用这项技术从药店获得 PM。在本文中，我们回顾了当前用于 PM 的药物制造方法的局限性、对 PM 最有益的三维 (3D) 打印技术、将这项技术引入药学实践的意义，以及围绕 PM 制造的 3D 打印技术的政策意义。
