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下调的循环长非编码 RNA GAS6-AS1 筛查和预测急性心肌梗死。

Downregulated Circulating Long Non-coding RNA GAS6-AS1 Screens and Predicts Acute Myocardial Infarction.

机构信息

Department of Emergency, Beijing JiShuiTan Hospital, Beijing, China.

出版信息

Anatol J Cardiol. 2023 Mar;27(3):167-172. doi: 10.14744/AnatolJCardiol.2022.2496.

DOI:10.14744/AnatolJCardiol.2022.2496
PMID:36856591
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC9995557/
Abstract

BACKGROUND

Acute myocardial infarction seriously threatens human health and life quality, which needs novel biomarkers to improve its early detection and development prediction. This study aimed to assess the potential of long non-coding RNA GAS6-AS1 in discriminating acute myocardial infarction patients and predicting patients' outcomes.

METHODS

The circulating expression of GAS6-AS1 in 83 acute myocardial infarction patients and 62 healthy individuals was evaluated using polymerase chain reaction. The value of GAS6-AS1 in the distinguishing acute myocardial infarction patients was evaluated with receiver operating characteristic analysis, and its prognosis predictive potential was assessed by Kaplan-Meier and Cox analysis. Additionally, the correlation of GAS6-AS1 with patients' critical features was evaluated by Spearman's correlation analysis.

RESULTS

Significant downregulation of GAS6-AS1 was observed in the plasma of acute myocardial infarction patients relative to healthy individuals. Reduced GAS6-AS1 could discriminate acute myocardial infarction patients from healthy controls and indicate patients' unoptimistic prognosis. Moreover, GAS6-AS1 was found to be negatively cor-related with the levels of creatine kinase, creatine kinasemyocardial bland, lactic dehy-drogenase, hydroxybutyrate dehydrogenase, troponin T, and positively correlated with the ejection fraction of acute myocardial infarction patients.

CONCLUSION

Changes in circulating GAS6-AS1 in acute myocardial infarction served as a potential diagnostic and prognostic biomarker of acute myocardial infarction.

摘要

背景

急性心肌梗死严重威胁人类健康和生活质量，需要新型生物标志物来提高其早期检测和发展预测能力。本研究旨在评估长链非编码 RNA GAS6-AS1 在区分急性心肌梗死患者和预测患者预后方面的潜力。

方法

采用聚合酶链反应检测 83 例急性心肌梗死患者和 62 例健康个体循环中 GAS6-AS1 的表达。采用受试者工作特征分析评估 GAS6-AS1 区分急性心肌梗死患者的价值，并采用 Kaplan-Meier 和 Cox 分析评估其预后预测潜力。此外，采用 Spearman 相关分析评估 GAS6-AS1 与患者危急特征的相关性。

结果

与健康个体相比，急性心肌梗死患者血浆中 GAS6-AS1 的表达显著下调。低表达的 GAS6-AS1 可区分急性心肌梗死患者和健康对照者，并提示患者预后不良。此外，GAS6-AS1 与肌酸激酶、肌酸激酶同工酶、乳酸脱氢酶、羟丁酸脱氢酶、肌钙蛋白 T 的水平呈负相关，与急性心肌梗死患者的射血分数呈正相关。

结论

急性心肌梗死患者循环中 GAS6-AS1 的变化可作为急性心肌梗死潜在的诊断和预后生物标志物。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/ed98/9995557/6188ac344378/ajc-27-3-167_f002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/ed98/9995557/f7b33d340276/ajc-27-3-167_f001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/ed98/9995557/6188ac344378/ajc-27-3-167_f002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/ed98/9995557/f7b33d340276/ajc-27-3-167_f001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/ed98/9995557/6188ac344378/ajc-27-3-167_f002.jpg

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