Yang Zhen, Fan Zejun, Wang Du, Li Hui, He Zihao, Xing Dan, Lin Jianhao
Arthritis Clinical and Research Center, Peking University People's Hospital, Beijing, China.
Arthritis Institute, Peking University, Beijing, China.
Front Bioeng Biotechnol. 2023 Feb 14;11:1107209. doi: 10.3389/fbioe.2023.1107209. eCollection 2023.
Meniscus injuries, a common joint disease caused by long-term wear, trauma and inflammation, usually cause chronic dysfunction and pain in the joint. Current clinical surgeries mainly aim to remove the diseased tissue to alleviate patient suffering instead of helping with meniscus regeneration. As an emerging treatment, stem cell therapy has been verified to facilitate meniscus regeneration effectively. The purpose of this study is to investigate the publication conditions of stem cell therapy for meniscal regeneration and to visualize the research trends and frontiers. Relevant publications relevant to stem cells for meniscal regeneration was retrieved SCI-Expanded of the Web of Science database from 2012 to 2022. Research trends in the field were analysed and visualized by CiteSpace and VOSviewer. A total of 354 publications were collected and analysed. The United States contributed the largest number of publications (118, 34.104%). Tokyo Medical Dental University has contributed the largest number of publications (34) among all full-time institutions. has published the largest number of researches on stem cells for meniscal regeneration (17). SEKIYA. I contributed the majority of publications in this field (31), while Horie, M was the most frequently cited authors (166). #1 tissue engineering, #2 articular cartilage, #3 anterior cruciate ligament, #4 regenerative medicine, #5 scaffold are the chief keywords. This indicates that the current research hotspot has been transformed from basic surgical research to tissue engineering. Stem cell therapy is a promising therapeutic method for meniscus regeneration. This is the first visualized and bibliometric study to thoroughly construct the development trends and knowledge structure in the research field of stem cell therapy for meniscal regeneration in the past 10 years. The results thoroughly summarize and visualize the research frontiers, which will shed light on the research direction of stem cell therapy for meniscal regeneration.
半月板损伤是一种由长期磨损、创伤和炎症引起的常见关节疾病，通常会导致关节慢性功能障碍和疼痛。目前的临床手术主要旨在切除病变组织以减轻患者痛苦，而非帮助半月板再生。作为一种新兴治疗方法，干细胞疗法已被证实能有效促进半月板再生。本研究的目的是调查半月板再生的干细胞疗法的发表情况，并可视化研究趋势和前沿。从2012年到2022年在科学网数据库的SCI扩展版中检索了与半月板再生的干细胞相关的出版物。通过CiteSpace和VOSviewer分析并可视化了该领域的研究趋势。共收集并分析了354篇出版物。美国的出版物数量最多（118篇，占34.104%）。东京医科齿科大学在所有全日制机构中发表的出版物数量最多（34篇）。SEKIYA. I发表的关于半月板再生的干细胞研究数量最多（17篇）。SEKIYA. I在该领域的出版物数量占多数（31篇），而Horie, M是被引用次数最多的作者（166次）。“#1组织工程”“#2关节软骨”“#3前交叉韧带”“#4再生医学”“#5支架”是主要关键词。这表明当前的研究热点已从基础外科研究转向组织工程。干细胞疗法是一种有前景的半月板再生治疗方法。这是第一项全面构建过去10年半月板再生的干细胞疗法研究领域发展趋势和知识结构的可视化文献计量学研究。研究结果全面总结并可视化了研究前沿，这将为半月板再生的干细胞疗法的研究方向提供启示。
