Dong Ping, Xu Qiong, Zhang Ying, Li Dong-Yun, Zhou Bing-Rui, Hu Chun-Chun, Liu Chun-Xue, Tang Xin-Rui, Fu Shi-Yun, Zhang Lan, Li Hai-Feng, Jia Fei-Yong, Tong Xiu-Bin, Wang Jie, Li Hui-Ping, Xu Xiu
Department of Child Healthcare, Children's Hospital of Fudan University, National Children's Medical Center, Shanghai, China.
Department of Child Healthcare, Chengdu Women's and Children's Central Hospital, Chengdu, China.
Front Pediatr. 2023 Feb 15;11:1052665. doi: 10.3389/fped.2023.1052665. eCollection 2023.
Early identification and intervention for children with global developmental delay (GDD) can significantly improve their prognosis and reduce the possibility of developing intellectual disability in the future. This study aimed to explore the clinical effectiveness of a parent-implemented early intervention program (PIEIP) for GDD, providing a research basis for the extended application of this intervention strategy in the future.
During the period between September 2019 and August 2020, children aged 3 to 6 months diagnosed with GDD were selected from each research center as the experimental group and the control group. For the experimental group, the PIEIP intervention was conducted for the parent-child pair. Mid-term and end-stage assessments were performed, respectively, at 12 and 24 months of age, and parenting stress surveys were completed.
The average age of the enrolled children was 4.56 ± 1.08 months for the experimental group ( = 153) and 4.50 ± 1.04 months for the control group ( = 153). The comparative analysis of the variation in the progress between the two groups by independent -test showed that, after the experimental intervention, the developmental quotient (DQ) of locomotor, personal-social, and language, as well as the general quotient (GQ) of the Griffiths Mental Development Scale-Chinese (GDS-C), the children in the experimental group demonstrated higher progress than those in the control group ( < 0.05). Furthermore, there was a significant decrease in the mean standard score of dysfunctional interaction, difficult children and the total level of parental stress in the term test for the experimental groups ( < 0.001 for all).
PIEIP intervention can significantly improve the developmental outcome and prognosis of children with GDD, especially in the areas of locomotor, personal-social, and language.
对全球发育迟缓（GDD）儿童进行早期识别和干预可显著改善其预后，并降低未来发生智力残疾的可能性。本研究旨在探讨家长实施的早期干预项目（PIEIP）对GDD的临床效果，为该干预策略未来的推广应用提供研究依据。
在2019年9月至2020年8月期间，从各研究中心选取3至6个月大、被诊断为GDD的儿童作为实验组和对照组。对实验组的亲子对进行PIEIP干预。分别在12个月和24个月龄时进行中期和末期评估，并完成育儿压力调查。
实验组（n = 153）入选儿童的平均年龄为4.56±1.08个月，对照组（n = 153）为4.50±1.04个月。通过独立样本t检验对两组进展变化进行比较分析，结果显示，经过实验干预后，实验组儿童在运动、个人社交和语言方面的发育商（DQ）以及格里菲斯心理发展量表中文版（GDS-C）的总商（GQ）方面的进展高于对照组（P < 0.05）。此外，实验组在学期测试中功能失调互动、难养儿童的平均标准分以及父母压力总水平均显著降低（均P < 0.001）。
PIEIP干预可显著改善GDD儿童的发育结局和预后，尤其是在运动、个人社交和语言方面。
