Abdolahi Nafiseh, Norouzi Alireza, Golsha Roghieh, Khodabakhshi Behnaz, Sohrabi Ahmad, Gharib Mohammad Hadi, Khandashpoor Mahmoud, Tavassoli Samane, Peivandi Babak, Fazel Abdolreza, Isapanah Amlashi Fazel, Livani Somayeh, Roshandel Gholamreza, Besharat Sima, Shirzad-Aski Hesamaddin
Golestan Rheumatology Research Center, Golestan University of Medical Sciences, Gorgan, Iran.
Golestan Research Center of Gastroenterology and Hepatology, Golestan University of Medical Sciences, Gorgan, Iran.
Tanaffos. 2022 Feb;21(2):146-153.
Considering the severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) pandemic, which causes coronavirus disease 2019 (COVID-19), we aimed to report the clinical features of 427 patients with COVID-19 and the outcomes after one-month admission to major teaching hospitals in the northeast of Iran.
Data of patients hospitalized with COVID-19 from 20 February 2020 to 20 April 2020 was analyzed using the R software. The cases and their outcomes were monitored up to one month following their admission.
Among 427 patients with a median age of 53 years (50.8% male), 81 (19%) were directly admitted to the ICU ward, and 68 (16%) died during the study. The mean (SD) lengths of hospital stay were significantly higher in the non-survivors (6 (9) days) than survivors (4 (5) days) (P = 0.018). Ventilation need was reported in 67.6% of the non-survivors and 0.8% of the survivors (P < 0.001). Cough (72.8%), fever (69.3%), and dyspnea (64.0%) were the most common symptoms. There were more comorbidities in the severe cases (73.5%) and non-survivor (77.5%). Liver and kidney damage were significantly more common in non-survivors. Ninety percent of the patients had at least one abnormal chest CT scan finding, including crazy paving and consolidation patterns (27.1%), followed by the ground-glass opacity (24.7%).
Results showed that the patients' age, underlying comorbidities, levels of SpO, and laboratory findings at the time of admission may predict the progress of the disease and can be considered mortality-related factors.
考虑到导致2019冠状病毒病（COVID-19）的严重急性呼吸综合征冠状病毒2（SARS-CoV-2）大流行，我们旨在报告427例COVID-19患者的临床特征以及在伊朗东北部主要教学医院入院一个月后的结局。
使用R软件分析2020年2月20日至2020年4月20日因COVID-19住院患者的数据。对病例及其结局进行入院后长达一个月的监测。
在427例中位年龄为53岁（50.8%为男性）的患者中，81例（19%）直接入住重症监护病房，68例（16%）在研究期间死亡。非幸存者的平均（标准差）住院时间（6（9）天）显著高于幸存者（4（5）天）（P = 0.018）。67.6%的非幸存者和0.8%的幸存者报告需要通气（P < 0.001）。咳嗽（72.8%）、发热（69.3%）和呼吸困难（64.0%）是最常见的症状。重症病例（73.5%）和非幸存者（77.5%）的合并症更多。非幸存者中肝损伤和肾损伤明显更常见。90%的患者至少有一项胸部CT扫描异常发现，包括铺路石样改变和实变模式（27.1%），其次是磨玻璃影（24.7%）。
结果表明，患者的年龄、潜在合并症、入院时的SpO水平和实验室检查结果可能预测疾病进展，并可被视为与死亡率相关的因素。
