耐多药分离株 SE690：导致国际上头孢曲松耐药的镶嵌基因已传播到更具抗菌药物敏感性的基因组谱系，瑞典，2022 年 9 月。
Multidrug-resistant isolate SE690: mosaic gene causing ceftriaxone resistance internationally has spread to the more antimicrobial-susceptible genomic lineage, Sweden, September 2022.
机构信息
WHO Collaborating Centre for Gonorrhoea and Other STIs, National Reference Laboratory for STIs, Department of Laboratory Medicine, Faculty of Medicine and Health, Ӧrebro University, Ӧrebro, Sweden.
Department of Clinical Microbiology, Karolinska University Hospital, Huddinge, Sweden.
出版信息
Euro Surveill. 2023 Mar;28(10). doi: 10.2807/1560-7917.ES.2023.28.10.2300125.
We report a ceftriaxone-resistant, multidrug-resistant urogenital in a female sex worker in Sweden, September 2022, who was treated with ceftriaxone 1 g, but did not return for test-of-cure. Whole genome sequencing of isolate SE690 identified MLST ST8130, NG-STAR CC1885 (new NG-STAR ST4859) and mosaic . The latter, causing ceftriaxone resistance in the internationally spreading FC428 clone, has now also spread to the more antimicrobial-susceptible genomic lineage B, showing that strains across the gonococcal phylogeny can develop ceftriaxone resistance.
我们报告了一例 2022 年 9 月在瑞典的一名女性性工作者中出现的对头孢曲松耐药、多种药物耐药的泌尿生殖道感染，该患者接受了 1 克头孢曲松治疗，但未进行治愈检测。分离株 SE690 的全基因组测序鉴定出 MLST ST8130、NG-STAR CC1885（新的 NG-STAR ST4859）和马赛克型。后者导致在国际上传播的 FC428 克隆对头孢曲松耐药，现在也已经传播到更具抗微生物敏感性的基因组谱系 B，表明淋病奈瑟菌系统发育树上的菌株都可能产生头孢曲松耐药性。
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