煤矿工人中的胃癌：最终报告。
Gastric cancer in coalminers: final report.
作者信息
Swaen G M, Aerdts C W, Slangen J J
机构信息
Department of Occupational Medicine, University of Limberg, Maastricht, The Netherlands.
出版信息
Br J Ind Med. 1987 Nov;44(11):777-9. doi: 10.1136/oem.44.11.777.
A matched case-control study was conducted to investigate the risk of gastric cancer in coalminers in the southern part of Limburg, The Netherlands. All 683 male cases of gastric cancer were identified at the five pathology departments in the area, all histologically confirmed by a pathologist. For each case a control patient, free of gastric cancer, was selected from the same pathology department, matched on date of birth. Of the 1366 patients enrolled in the study, an occupational history was collected regarding previous employment in a Dutch coal mine. Of the patients with gastric cancer, 28% had been employed as underground workers in a coalmine compared with 25% of the control group. The odds ratio for underground coalmining and gastric cancer was 1.15 (95% confidence limits: 0.89-1.47). There was no evidence for the existence of a dose-response relation. It was concluded that the study did not provide support for the hypothesis that underground coalmining increases the risk of gastric cancer.
在荷兰林堡省南部开展了一项配对病例对照研究，以调查煤矿工人患胃癌的风险。该地区五个病理科共识别出683例男性胃癌病例，所有病例均经病理学家组织学确诊。为每例病例从同一病理科挑选一名未患胃癌的对照患者，按出生日期进行配对。在参与研究的1366名患者中，收集了他们以前在荷兰煤矿工作的职业史。胃癌患者中，28%曾在煤矿从事井下工作，而对照组这一比例为25%。井下采煤与胃癌的比值比为1.15（95%置信区间：0.89 - 1.47）。没有证据表明存在剂量反应关系。研究得出结论，该研究不支持井下采煤会增加胃癌风险这一假设。
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