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唇腭裂:最常见的先天性畸形之一。

[Cleft lip and palate : One of the most frequent congenital malformations].

作者信息

Lauer Günter, Pradel Winnie, Birdir Cahit

机构信息

Klinik und Poliklinik für Mund‑, Kiefer- und Gesichtschirurgie, Universitätsklinikum Carl Gustav Carus, Technische Universität Dresden, Fetscherstr. 74, 01307, Dresden, Deutschland.

Universitäts Kinder-Frauenzentrum, Klinik und Poliklinik für Frauenheilkunde und Geburtshilfe, Universitätsklinikum Carl Gustav Carus, Technische Universität Dresden, Dresden, Deutschland.

出版信息

HNO. 2023 Apr;71(4):276-284. doi: 10.1007/s00106-023-01291-0.

DOI:10.1007/s00106-023-01291-0
PMID:36897341
Abstract

With a frequency of 1 per 500 live births, a cleft lip and palate is one of the most frequent congenital malformations. Untreated, it leads to disturbances in feeding, speech, hearing, tooth position and esthetics. A multifactorial genesis is assumed. The fusion of the different facial processes takes place in the first 3 months of pregnancy and a cleft can develop during this time. Surgical treatment includes the early anatomical and functional restoration of the affected structures within the first year of life in order to enable normal intake of food, articulation, nasal breathing and middle ear ventilation. Breastfeeding is possible in children with a cleft formation but alternative feeding methods, such as finger feeding, often have to be used. In addition to the surgery for primary closure of the cleft, otorhinolaryngological (ENT) interventions, speech therapy, orthodontic treatment as well as other surgical interventions are part of the interdisciplinary treatment concept.

摘要

唇腭裂是最常见的先天性畸形之一,每500例活产中就有1例发生。若不治疗,会导致喂养、言语、听力、牙齿位置和美观方面的障碍。一般认为其病因是多因素的。不同面部结构的融合在怀孕的前3个月进行,在此期间可能会出现腭裂。手术治疗包括在生命的第一年内对受影响结构进行早期解剖和功能修复,以实现正常进食、发音、鼻呼吸和中耳通气。有腭裂的儿童可以进行母乳喂养,但通常需要使用替代喂养方法,如手指喂食。除了腭裂一期闭合手术外,耳鼻喉科(ENT)干预、言语治疗、正畸治疗以及其他手术干预也是跨学科治疗理念的一部分。

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1
[Cleft lip and palate : One of the most frequent congenital malformations].唇腭裂:最常见的先天性畸形之一。
HNO. 2023 Apr;71(4):276-284. doi: 10.1007/s00106-023-01291-0.
2
[Differential diagnosis and treatment of cheilognathopalatoschises].[唇腭裂的鉴别诊断与治疗]
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[The child with lip, maxillary, palatal cleft].患有唇裂、上颌裂和腭裂的儿童
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Folia Phoniatr Logop. 1998 Nov-Dec;50(6):320-34. doi: 10.1159/000021474.
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Minerva Stomatol. 2014 Apr;63(4):111-26.
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A Scandcleft randomised trials of primary surgery for unilateral cleft lip and palate: 1. Planning and management.单侧唇腭裂一期手术的斯堪的纳维亚腭裂随机试验:1. 规划与管理
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Int J Oral Maxillofac Surg. 2012 Feb;41(2):192-9. doi: 10.1016/j.ijom.2011.10.030. Epub 2011 Nov 27.
10
Minimal standards for reporting the results of surgery on patients with cleft lip, cleft palate, or both: a proposal.唇腭裂或唇腭裂合并患者手术结果报告的最低标准:一项提议。
Cleft Palate J. 1988 Jan;25(1):3-7.

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Association between elevated maternal serum MSX1 and IRF6 levels and fetal orofacial clefts: implications for clinical prediction.孕妇血清中MSX1和IRF6水平升高与胎儿口面部裂隙之间的关联:对临床预测的意义
Am J Transl Res. 2025 Apr 15;17(4):2541-2551. doi: 10.62347/ZDZC2364. eCollection 2025.
2
Perception, attitude, and opinion of parents of cleft lip and palate patients treated with nasoalveolar molding (NAM): A cross-sectional questionnaire study.接受鼻牙槽骨塑形(NAM)治疗的唇腭裂患者家长的认知、态度和看法:一项横断面问卷调查研究
Int J Paediatr Dent. 2025 Jul;35(4):698-707. doi: 10.1111/ipd.13279. Epub 2024 Oct 25.

本文引用的文献

1
ISUOG Practice Guidelines (updated): performance of the routine mid-trimester fetal ultrasound scan.国际妇产科超声学会(ISUOG)实践指南(更新版):孕中期常规胎儿超声检查的实施
Ultrasound Obstet Gynecol. 2022 Jun;59(6):840-856. doi: 10.1002/uog.24888. Epub 2022 May 20.
2
Fetal markers for the detection of infants with craniofacial malformation.用于检测患有颅面畸形婴儿的胎儿标志物。
Semin Fetal Neonatal Med. 2021 Dec;26(6):101291. doi: 10.1016/j.siny.2021.101291. Epub 2021 Sep 20.
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Adenoidectomy for middle ear disease in cleft palate children: a systematic review.
腭裂儿童中耳疾病的腺样体切除术:系统评价。
Eur Arch Otorhinolaryngol. 2022 Mar;279(3):1175-1180. doi: 10.1007/s00405-021-07035-6. Epub 2021 Aug 28.
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Surgical management in submucous cleft palate patients.黏膜下裂腭裂患者的手术治疗。
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Orthodontics for Unilateral and Bilateral Cleft Deformities.单侧及双侧唇腭裂畸形的正畸治疗
Oral Maxillofac Surg Clin North Am. 2020 May;32(2):297-307. doi: 10.1016/j.coms.2020.01.011. Epub 2020 Mar 6.
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Otologic, audiometric and speech findings in patients undergoing surgery for cleft palate.耳科学、听力学和语音学在腭裂手术患者中的表现。
BMC Pediatr. 2018 Nov 8;18(1):350. doi: 10.1186/s12887-018-1312-7.
7
Current concepts in cleft care: A multicenter analysis.当前的腭裂护理理念:一项多中心分析。
J Craniomaxillofac Surg. 2018 Apr;46(4):705-708. doi: 10.1016/j.jcms.2018.01.014. Epub 2018 Feb 6.
8
Otologic Concerns for Cleft Lip and Palate Patient.唇腭裂患者的耳科问题
Oral Maxillofac Surg Clin North Am. 2016 May;28(2):177-9. doi: 10.1016/j.coms.2015.12.001. Epub 2016 Feb 1.
9
Contemporary management of cleft lip and palate in the United Kingdom. Have we reached the turning point?英国唇腭裂的当代治疗。我们是否已到转折点?
Br J Oral Maxillofac Surg. 2015 Sep;53(7):594-8. doi: 10.1016/j.bjoms.2015.06.010. Epub 2015 Jun 27.
10
Revision rates and speech outcomes following pharyngeal flap surgery for velopharyngeal insufficiency.腭咽闭合不全患者行咽瓣手术后的修复率及语音结果
JAMA Facial Plast Surg. 2015 May-Jun;17(3):197-201. doi: 10.1001/jamafacial.2015.0093.