Diakos Alda, Silva Maria Leonor, Brito José, Moncada Margarida, de Mesquita Maria Fernanda, Bernardo Maria Alexandra
Centro de Investigação Interdisciplinar Egas Moniz (CiiEM), Instituto Universitário Egas Moniz, Campus Universitário, Quinta da Granja, Monte de Caparica, 2829-511 Caparica, Portugal.
Foods. 2023 Mar 1;12(5):1037. doi: 10.3390/foods12051037.
Ginger has shown beneficial effects on blood glucose control due to its antioxidant and anti-inflammatory properties. The present study investigated the effect of ginger aqueous extract on postprandial glucose levels in nondiabetic adults and characterized its antioxidant activity. Twenty-four nondiabetic participants were randomly assigned into two groups (NCT05152745), the intervention group (n = 12) and the control group (n = 12). Both groups were administered 200 mL of an oral glucose tolerance test (OGTT), after which participants in the intervention group ingested 100 mL of ginger extract (0.2 g/100 mL). Postprandial blood glucose was measured while fasting and after 30, 60, 90, and 120 min. The total phenolic content, flavonoid content, and antioxidant activity of ginger extract were quantified. In the intervention group, the incremental area under the curve for glucose levels decreased significantly ( < 0.001) and the maximum glucose concentration significantly reduced ( < 0.001). The extract possessed a polyphenolic content of 13.85 mg gallic acid equivalent/L, a flavonoid content of 3.35 mg quercetin equivalent/L, and a high superoxide radical inhibitory capacity (45.73%). This study showed that ginger has a beneficial effect on glucose homeostasis under acute conditions and encourages the use of ginger extract as a promising source of natural antioxidants.
生姜因其抗氧化和抗炎特性，已显示出对血糖控制有益的作用。本研究调查了生姜水提取物对非糖尿病成年人餐后血糖水平的影响，并对其抗氧化活性进行了表征。24名非糖尿病参与者被随机分为两组（NCT05152745），即干预组（n = 12）和对照组（n = 12）。两组均接受200 mL口服葡萄糖耐量试验（OGTT），之后干预组参与者摄入100 mL生姜提取物（0.2 g/100 mL）。在空腹以及30、60、90和120分钟后测量餐后血糖。对生姜提取物的总酚含量、黄酮含量和抗氧化活性进行了定量分析。在干预组中，血糖水平的增量曲线下面积显著降低（<0.001），最大血糖浓度显著降低（<0.001）。该提取物的多酚含量为13.85 mg没食子酸当量/L，黄酮含量为3.35 mg槲皮素当量/L，具有较高的超氧自由基抑制能力（45.73%）。本研究表明，生姜在急性条件下对葡萄糖稳态具有有益作用，并鼓励将生姜提取物作为一种有前景的天然抗氧化剂来源加以使用。
