Faculty of Pharmacy, Rhodes University, Makhanda 6140, South Africa.
Department of Biological Sciences, University of Cape Town, Rondebosch 7701, South Africa.
Molecules. 2023 Feb 22;28(5):2063. doi: 10.3390/molecules28052063.
South Africa's highly diverse marine biota includes several endemic marine red algae of the genus. Cryptic species and morphological variability make the taxonomy of plant challenging, and a record of the secondary metabolites isolated from South African spp. can be used to assess their chemotaxonomic significance. In addition, the rapid development of resistance against antibiotics, coupled with the inherent ability of seaweeds to resist pathogenic infection, supported this first phycochemical investigation of J. Agardh. A new tricyclic keto-cuparane () and two new cuparanes () were obtained alongside known acetogenins, halo-chamigranes, and additional cuparanes. These compounds were screened against , , , , and , with exhibiting excellent activity against the Gram-negative (minimum inhibitory concentration (MIC) 1 μg/mL) strain.
南非高度多样化的海洋生物群包括几种属于的特有海洋红藻。隐种和形态变异性使得植物的分类学具有挑战性，并且可以从南非的次生代谢产物记录中评估它们的化学分类学意义。此外，抗生素耐药性的迅速发展，加上海藻抵抗病原感染的固有能力，支持了对 J. Agardh 的首次植物化学研究。除了已知的乙酰基化合物、卤代查米格兰、和其他杯烷外，还获得了一种新的三环酮杯烷（）和两种新的杯烷（）。这些化合物针对、、、和进行了筛选，其中化合物表现出对革兰氏阴性（最小抑菌浓度（MIC）为 1 μg/mL）菌株的优异活性。
