Chockattu Sherin Jose, Deepak B S, Goud K Mallikarjun
Department of Conservative Dentistry and Endodontics, Bapuji Dental College and Hospital, Davangere, Karnataka, India.
Department of Conservative Dentistry and Endodontics, Dental College, RIMS, Imphal, Manipur, India.
J Conserv Dent. 2018 Jan-Feb;21(1):80-84. doi: 10.4103/JCD.JCD_349_16.
One of the important goals of root canal therapy is disinfection aided by irrigation and intracanal medicaments. Commonly used nonsteroidal anti-inflammatory agents have shown anti-bacterial activity, thus, when used as intracanal medicaments, nonantibiotic agents have the potential to provide anti-inflammatory, local analgesic, and anti-bacterial activity.
The aim of this study is to evaluate and compare the anti-bacterial efficiency of anti-inflammatory nonantibiotics ibuprofen and diclofenac, and routinely used intracanal dressing calcium hydroxide (Ca[OH]), against , in an endodontic model.
A total of 76 single-rooted mandibular premolar teeth were decoronated and instrumented up to F4-ProTaper rotary. Apical foramen was sealed with composite resin, and all external surfaces made impermeable with nail varnish, except for coronal access. Roots were autoclaved (121°C for 20 min), placed in Eppendorf tubes, and contaminated with for 14 days. Colony-forming unit (CFU) counts were taken before (CFU-1), and after intracanal medication (CFU-2) by paper point sampling. Test medicaments (Group-1: ibuprofen, Group-2: diclofenac, Group-3: Ca[OH]) were mixed with distilled water (1:1 w/v), placed into root canals, temporarily sealed, and incubated (37°C; 7 days). Group-4 received no medicament (control). Kruskal-Wallis ANOVA was used to compare the four groups and Mann-Whitney U-test for pair-wise comparisons.
Within the limitations of the study, anti-inflammatory nonantibiotics (ibuprofen; diclofenac) were shown to have anti-bacterial effect against .
Since nonsteroidal anti-inflammatory drugs (NSAIDs) have an anti-bacterial effect, it is possible to replace Ca(OH) with NSAIDs, or even combine them to form a cocktail of local disinfectants to optimize canal disinfection.
根管治疗的重要目标之一是通过冲洗和根管内药物辅助进行消毒。常用的非甾体抗炎药已显示出抗菌活性，因此，当用作根管内药物时，非抗生素药物有可能提供抗炎、局部镇痛和抗菌活性。
本研究的目的是在牙髓病模型中评估和比较抗炎非抗生素布洛芬和双氯芬酸以及常规使用的根管内敷料氢氧化钙（Ca[OH]）对[具体细菌名称未给出]的抗菌效率。
总共76颗单根下颌前磨牙去冠并预备至F4-ProTaper旋转锉。根尖孔用复合树脂封闭，除冠部入口外，所有外表面用指甲油使其不透水。将牙根高压灭菌（121°C，20分钟），放入Eppendorf管中，并用[具体细菌名称未给出]污染14天。通过纸尖取样在根管内用药前（CFU-1）和用药后（CFU-2）进行菌落形成单位（CFU）计数。将测试药物（第1组：布洛芬，第2组：双氯芬酸，第3组：Ca[OH]）与蒸馏水按1:1（w/v）混合，放入根管内，临时封闭，并孵育（37°C；7天）。第4组不使用药物（对照组）。采用Kruskal-Wallis方差分析比较四组，采用Mann-Whitney U检验进行两两比较。
在本研究的局限性范围内，抗炎非抗生素（布洛芬；双氯芬酸）对[具体细菌名称未给出]显示出抗菌作用。
由于非甾体抗炎药（NSAIDs）具有抗菌作用，有可能用NSAIDs替代Ca(OH)，甚至将它们联合形成局部消毒剂混合物以优化根管消毒。
