Department of Pharmacy, The Affiliated Hospital of Southwest Medical University, Luzhou, China.
School of Pharmacy, Southwest Medical University, Luzhou, China.
Front Endocrinol (Lausanne). 2023 Feb 24;14:1098881. doi: 10.3389/fendo.2023.1098881. eCollection 2023.
Over the past few decades, increasing prevalence of obesity caused an enormous medical, social, and economic burden. As the sixth most important risk factor contributing to the overall burden of disease worldwide, obesity not only directly harms the human body, but also leads to many chronic diseases such as diabetes, cardiovascular diseases (CVD), nonalcoholic fatty liver disease (NAFLD), and mental illness. Weight loss is still one of the most effective strategies against obesity and related disorders. Recently, the link between intestinal microflora and metabolic health has been constantly established. Butyrate, a four-carbon short-chain fatty acid, is a major metabolite of the gut microbiota that has many beneficial effects on metabolic health. The anti-obesity activity of butyrate has been demonstrated, but its mechanisms of action have not been fully described. This review summarizes current knowledge of butyrate, including its production, absorption, distribution, metabolism, and the effect and mechanisms involved in weight loss and obesity-related diseases. The aim was to contribute to and advance our understanding of butyrate and its role in obesity. Further exploration of butyrate and its pathway may help to identify new anti-obesity.
在过去的几十年中，肥胖症的发病率不断上升，给医疗、社会和经济带来了巨大的负担。肥胖作为全球疾病负担的第六大重要危险因素，不仅直接危害人体健康，还会导致许多慢性疾病，如糖尿病、心血管疾病（CVD）、非酒精性脂肪肝（NAFLD）和精神疾病。减肥仍然是对抗肥胖和相关疾病最有效的策略之一。最近，肠道微生物群与代谢健康之间的联系不断得到确立。丁酸盐是一种四碳短链脂肪酸，是肠道微生物群的主要代谢产物，对代谢健康有许多有益的影响。丁酸盐的抗肥胖活性已得到证实，但它的作用机制尚未完全描述。本综述总结了丁酸盐的最新知识，包括其生产、吸收、分布、代谢，以及在减肥和肥胖相关疾病中涉及的作用和机制。目的是为了增进和推进我们对丁酸盐及其在肥胖中的作用的理解。进一步探索丁酸盐及其途径可能有助于发现新的抗肥胖方法。
