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整合转录组学和代谢组学分析揭示了新型银核壳纳米系统抗肿瘤潜力相关的生物分子机制。

Integrated transcriptomics and metabolomics analysis reveals the biomolecular mechanisms associated to the antitumoral potential of a novel silver-based core@shell nanosystem.

机构信息

Department of Analytical Chemistry, Faculty of Chemical Sciences, Complutense University of Madrid, 28040, Madrid, Spain.

Department of Chemistry in Pharmaceutical Sciences, Faculty of Pharmacy, Complutense University of Madrid, Instituto de Investigación Sanitaria Hospital, 12 de Octubre (I+12), 28040, Madrid, Spain.

出版信息

Mikrochim Acta. 2023 Mar 13;190(4):132. doi: 10.1007/s00604-023-05712-3.

DOI:10.1007/s00604-023-05712-3
PMID:36914921
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC10011303/
Abstract

A combination of omics techniques (transcriptomics and metabolomics) has been used to elucidate the mechanisms responsible for the antitumor action of a nanosystem based on a Ag core coated with mesoporous silica on which transferrin has been anchored as a targeting ligand against tumor cells (Ag@MSNs-Tf). Transcriptomics analysis has been carried out by gene microarrays and RT-qPCR, while high-resolution mass spectrometry has been used for metabolomics. This multi-omics strategy has enabled the discovery of the effect of this nanosystem on different key molecular pathways including the glycolysis, the pentose phosphate pathway, the oxidative phosphorylation and the synthesis of fatty acids, among others.

摘要

采用组学技术（转录组学和代谢组学）来阐明基于 Ag 核的纳米系统的抗肿瘤作用机制，该纳米系统的核表面涂有介孔硅，其上锚定了转铁蛋白作为针对肿瘤细胞的靶向配体（Ag@MSNs-Tf）。通过基因微阵列和 RT-qPCR 进行转录组学分析，而高分辨率质谱用于代谢组学分析。这种多组学策略使我们能够发现该纳米系统对不同关键分子途径的影响，包括糖酵解、磷酸戊糖途径、氧化磷酸化和脂肪酸合成等。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/c71c/10011303/6edf5d1c2076/604_2023_5712_Fig4_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/c71c/10011303/3a79fbc19b19/604_2023_5712_Fig1_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/c71c/10011303/9969f238e2de/604_2023_5712_Fig2_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/c71c/10011303/8239d8aaa001/604_2023_5712_Fig3_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/c71c/10011303/6edf5d1c2076/604_2023_5712_Fig4_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/c71c/10011303/3a79fbc19b19/604_2023_5712_Fig1_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/c71c/10011303/9969f238e2de/604_2023_5712_Fig2_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/c71c/10011303/8239d8aaa001/604_2023_5712_Fig3_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/c71c/10011303/6edf5d1c2076/604_2023_5712_Fig4_HTML.jpg

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