嗅球弥散张量成像在 COVID-19 相关嗅觉障碍中的应用：一项初步研究。
DTI of the Olfactory Bulb in COVID-19-Related Anosmia: A Pilot Study.
机构信息
From the Departments of Radiology (F.S., A.H.E., A.A.R., M.M.G.).
From the Departments of Radiology (F.S., A.H.E., A.A.R., M.M.G.)
出版信息
AJNR Am J Neuroradiol. 2022 Aug;43(8):1180-1183. doi: 10.3174/ajnr.A7590.
Abstract
This study aimed to assess the utility of DTI in the detection of olfactory bulb dysfunction in COVID-19-related anosmia. It was performed in 62 patients with COVID-19-related anosmia and 23 controls. The mean diffusivity and fractional anisotropy were calculated by 2 readers. The difference between the fractional anisotropy and mean diffusivity values of anosmic and control olfactory bulbs was statistically significant ( = .001). The threshold of fractional anisotropy and mean diffusivity to differentiate a diseased from normal olfactory bulb were 0.22 and 1.5, with sensitivities of 84.4% and 96.8%, respectively, and a specificity of 100%.
摘要
本研究旨在评估 DTI 在检测 COVID-19 相关嗅觉丧失中嗅球功能障碍的效用。该研究纳入了 62 例 COVID-19 相关嗅觉丧失患者和 23 例对照。由 2 位读者计算平均弥散度和各向异性分数。嗅球和对照组的各向异性分数和平均弥散度值之间存在统计学差异（=0.001）。区分病变嗅球和正常嗅球的各向异性分数和平均弥散度阈值分别为 0.22 和 1.5，其灵敏度分别为 84.4%和 96.8%，特异性为 100%。
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