Stock-Damge C, Lhoste E, Aprahamian M, Pousse A
INSERM, Unit 61, Digestive Cell Biology and Physiopathology, Strasbourg, France.
Gut. 1987;28 Suppl(Suppl):1-7. doi: 10.1136/gut.28.suppl.1.
Bombesin administered subcutaneously to rats, three times daily for four days, induces pancreatic growth at a dose of 10 micrograms/kg. Growth was characterised by an increased pancreatic weight and content in protein and RNA, accompanied by cellular hypertrophy. Chronic bombesin also enhanced the pancreatic content in chymotrypsin and to a lesser degree its contents in amylase and lipase. The volume of the secretion and the output of enzymes in response to CCK under an infusion of secretin, however, remained unchanged although the functional capacity of individual cells to secret amylase and lipase was reduced. It is concluded that chronic bombesin exerts a trophic action on the rat pancreas but decreases the sensitivity of each cell to hormonal stimulation.
给大鼠皮下注射蛙皮素，每天3次，共4天，剂量为10微克/千克时可诱导胰腺生长。其生长特征为胰腺重量增加，蛋白质和RNA含量增多，并伴有细胞肥大。长期使用蛙皮素还可提高胰腺中糜蛋白酶的含量，对淀粉酶和脂肪酶含量的提高程度较小。然而，在注射促胰液素的情况下，尽管单个细胞分泌淀粉酶和脂肪酶的功能能力降低，但对胆囊收缩素（CCK）的分泌量和酶输出量仍保持不变。结论是，长期使用蛙皮素对大鼠胰腺具有营养作用，但会降低每个细胞对激素刺激的敏感性。
