长期胰胆转流刺激大鼠胰腺中的增生性和腺瘤性结节：一种自发性肿瘤形成的新模型。

Stace N H, Palmer T J, Vaja S, Dowling R H

Gastroenterology Unit, Division of Medicine, UMDS of Guy's Hospital, London.

Gut. 1987;28 Suppl(Suppl):265-8. doi: 10.1136/gut.28.suppl.265.

A model for spontaneous tumour formation in the rat pancreas is described that requires neither cocarcinogens nor dietary manipulation. Short term hypercholecystokininaemia, when induced by raw soya flour feeding, induces benign and malignant tumours of the rat pancreas. Pancreaticobiliary diversion (PBD) results in hypercholecystokininaemia and in the short term, pancreatic hyperplasia. Longterm PBD was done to establish whether hypercholecystokininaemia thus produced would also lead to pancreatic neoplasia. After a period of 16-21 months hyperplastic and adenomatous nodules, one of the latter showing carcinoma in situ, were found in PBD rats but not in sham operated control rats.

本文描述了一种大鼠胰腺自发性肿瘤形成模型，该模型既不需要促癌剂，也不需要饮食干预。通过喂食生大豆粉诱导短期高胆囊收缩素血症，可诱发大鼠胰腺的良性和恶性肿瘤。胰胆管改道（PBD）会导致高胆囊收缩素血症，并在短期内引起胰腺增生。进行长期PBD以确定由此产生的高胆囊收缩素血症是否也会导致胰腺肿瘤形成。在16 - 21个月后，在接受PBD的大鼠中发现了增生性和腺瘤性结节，其中一个腺瘤性结节显示原位癌，而在假手术对照组大鼠中未发现。