Institute for Medical Informatics, Biometry and Epidemiology (IMIBE), University Hospital Essen, University Duisburg-Essen, Essen, Germany.
Department of Dermatology and Venereology, HIV Outpatient Clinic, University Hospital Essen, University Duisburg-Essen, Essen, Germany.
Infection. 2023 Aug;51(4):1081-1091. doi: 10.1007/s15010-023-02009-8. Epub 2023 Mar 17.
Overweight and obesity have increased in people living with HIV (PLH). Our study evaluated weight, body-mass-index (BMI), and waist-to-hip ratio (WHR) change over 5 years of follow-up in PLH compared to the general population.
HIV-positive participants in the HIV Heart Aging (HIVH) study were matched 1:2 by age and sex with HIV-negative controls of the population-based Heinz Nixdorf Recall (HNR) study. Both studies were recruited in the German Ruhr area. The association between HIV and weight, BMI, and WHR changes was examined using linear regression. Regression models were adjusted for parameters potentially affecting weight gain.
The matched HIVH and HNR participants (N = 585 and N = 1170, respectively; 14.7% females) had a mean age of 55 years at baseline. Despite the lower baseline weight (- 6 kg, 95% CI - 7.46 to - 4.59), the linear regression showed greater absolute and relative weight and BMI increases after 5 years in HIVH compared to HNR. Adjusting the linear regression models for smoking amplified that HIVH had a higher absolute and relative weight difference of 0.7 kg or ~ 1% compared to HNR after 5 years (95% Cl 0.1 to 1.3 and 0.2 to 1.6, respectively). Adjusting for HDL, LDL, systolic blood pressure, and diabetes mellitus did not affect the results.
PLH had lower weight than the general population at baseline and after 5 years, but experienced greater increases in body weight after 5 years. WHR change after 5 years was lower in PLH compared to the general population, despite a higher WHR at baseline.
艾滋病毒感染者（PLH）的超重和肥胖问题有所增加。我们的研究评估了 PLH 在 5 年随访期间体重、体重指数（BMI）和腰臀比（WHR）的变化，并与普通人群进行了比较。
HIV 阳性参与者来自 HIV 心脏老化（HIVH）研究，根据年龄和性别与人群为基础的海因茨·尼克斯多夫召回（HNR）研究中的 HIV 阴性对照进行 1:2 匹配。这两项研究均在德国鲁尔地区招募。使用线性回归评估 HIV 与体重、BMI 和 WHR 变化之间的关联。回归模型调整了可能影响体重增加的参数。
匹配的 HIVH 和 HNR 参与者（N=585 和 N=1170，分别为 14.7%女性）的基线平均年龄为 55 岁。尽管基线体重较低（-6 公斤，95%置信区间为-7.46 至-4.59），但线性回归显示，与 HNR 相比，HIVH 在 5 年后体重和 BMI 的绝对值和相对值增加更多。在调整了吸烟因素的线性回归模型中，HIVH 与 HNR 相比，5 年后体重的绝对差值和相对差值更大，分别为 0.7 公斤或~1%（95%Cl 为 0.1 至 1.3 和 0.2 至 1.6）。调整高密度脂蛋白、低密度脂蛋白、收缩压和糖尿病对结果没有影响。
PLH 在基线和 5 年后的体重均低于普通人群，但在 5 年后体重增加更多。尽管基线时 WHR 较高，但与普通人群相比，PLH 在 5 年后的 WHR 变化较低。
