Center of Digital Dentistry/ Department of Prosthodontics, National Center of Stomatology, National Clinical Research Center for Oral Diseases, National Engineering Laboratory for Digital and Material Technology of Stomatology, Beijing Key Laboratory of Digital Stomatology, NHC Research Center of Engineering and Technology for Computerized Dentistry, Peking University School and Hospital of Stomatology, Beijing, 100081, P. R. China.
State Key Laboratory on Integrated Optoelectronics, Institute of Semiconductors, Chinese Academy of Sciences, Beijing, 100083, P. R. China.
Adv Sci (Weinh). 2023 May;10(14):e2203472. doi: 10.1002/advs.202203472. Epub 2023 Mar 19.
Non-invasive light-based antibacterial therapy has a good prospect in non-surgical treatment of peri-implant infections. However, its applications are severely limited by poor penetration of light into human tissues, leading to unsatisfying outcomes. Moreover, as an essential prerequisite for traditional light therapy, lasers can no longer meet the patients' needs for convenient treatment at any time. To break through the spatial and temporal limitations of traditional light therapy, a wireless-powered blue-light zirconia implant for readily available treatment of peri-implant infection is proposed. In space, complete irradiation to complex peri-implant structure is realized by the built-in wireless-powered light source, thus improving the efficacy. In time, wireless-powering allows timely and controllable anti-infection treatment. Blue micro-light emitting diodes are used as therapeutic light sources, which effectively kill peri-implant infection-related bacteria without exogenous photosensitive agents. Porphyromonas gingivalis biofilm on implant surface can be completely killed after 20 min irradiation in vitro. The bactericidal rate of peri-implant methicillin-resistant Staphylococcus aureus infection reaches 99.96 ± 0.03% under 30 min per day blue light exposure in vivo. Within the scope of this study, the treatment of peri-implant infection with blue-light implant has preliminary feasibility, giving a new approach to non-invasive treatment of deep oral infections, including peri-implant infections.
基于非侵入性的光疗技术在非手术治疗种植体周围感染方面具有广阔的应用前景。然而，由于光在人体组织中的穿透力差，其应用受到严重限制，导致治疗效果不尽如人意。此外，作为传统光疗的必要前提，激光已无法满足患者随时随地接受便捷治疗的需求。为了突破传统光疗的时空限制，提出了一种无线供电的蓝光氧化锆种植体，可随时用于治疗种植体周围感染。在空间上，内置的无线供电光源可实现对复杂种植体结构的完全照射，从而提高疗效。在时间上，无线供电可实现及时、可控的抗感染治疗。蓝色微型发光二极管被用作治疗光源，无需外源性光敏剂即可有效杀灭与种植体周围感染相关的细菌。体外照射 20 分钟后，可完全杀灭种植体表面牙龈卟啉单胞菌生物膜。体内每天 30 分钟的蓝光照射可使种植体周围耐甲氧西林金黄色葡萄球菌感染的杀菌率达到 99.96±0.03%。在本研究范围内，蓝光种植体治疗种植体周围感染具有初步可行性，为包括种植体周围感染在内的深部口腔感染的非侵入性治疗提供了新方法。
