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免疫生物学在相互关联的动物科学课程体系中的相关性日益增强。

The increasing relevance of immunobiology within a connected animal science curriculum.

作者信息

Meade Kieran G

机构信息

School of Agriculture and Food Science, University College Dublin, Belfield, Dublin 4, Ireland.

Conway Institute of Biomolecular and Biomedical Science, University College Dublin, Belfield, Dublin 4, Ireland.

出版信息

Transl Anim Sci. 2023 Jan 14;7(1):txad007. doi: 10.1093/tas/txad007. eCollection 2023 Jan.

DOI:10.1093/tas/txad007
PMID:36935864
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC10015800/
Abstract

Modern technological agriculture emerged in the 20th century and has expanded into a global enterprise occupying approximately 38% of the Earth's land area and accounting for over 40% of the world's workforce. The United Nations Food and Agriculture Organization estimates that to feed a world population of 9-billion people in 2050 will require an almost doubling of overall food production, including meat, dairy, and egg production over 2010 levels. However, our collective ability to meet this demand cannot be taken for granted. Despite many successes, global agricultural systems now face multiple unprecedented challenges including a dearth of new treatments for livestock diseases. The discovery of antibiotics led to a complacency now reflected in a dependency on exogenous antimicrobials and a growing threat of antimicrobial resistance. Developments within the field of immunobiology had led to significant breakthroughs in understanding of human health and disease. However, despite over 60% of infectious diseases being zoonotic in nature and nonhuman animals acting as an important disease reservoir, research in livestock immunobiology has not been as resourced. As a direct result, recalcitrant animal diseases continue to threaten sustainability of animal production systems, security of the food chain and human health. It is within the context of collective One Health action that ambitious innovation in the connectivity of animal science undergraduate curricula is urgently required, specifically to include threshold concepts in immunobiology. Fostering transformative learning is critical to equip future generations of animal scientists with the knowledge and interdisciplinary skills to counter these existential challenges of our time.

摘要

现代科技农业兴起于20世纪,并已发展成为一个全球性产业,占据了地球约38%的陆地面积,雇佣了全球超过40%的劳动力。联合国粮食及农业组织估计,要在2050年养活90亿人口的世界,总体粮食产量,包括肉类、奶制品和蛋类产量,需要在2010年的基础上几乎翻一番。然而,我们满足这一需求的集体能力并非理所当然。尽管取得了许多成功,但全球农业系统现在面临着多重前所未有的挑战,包括缺乏针对家畜疾病的新疗法。抗生素的发现导致了一种自满情绪,现在表现为对外源抗菌药物的依赖以及抗菌药物耐药性威胁的日益增加。免疫生物学领域的发展在人类健康和疾病的理解方面取得了重大突破。然而,尽管超过60%的传染病本质上是人畜共患病,非人类动物是重要的疾病宿主,但家畜免疫生物学的研究资源却不足。直接结果是,顽固的动物疾病继续威胁着动物生产系统的可持续性、食物链安全和人类健康。正是在“同一个健康”集体行动的背景下,迫切需要在动物科学本科课程的关联性方面进行大胆创新,特别是要纳入免疫生物学的阈值概念。促进变革性学习对于使下一代动物科学家具备应对我们这个时代这些生存挑战的知识和跨学科技能至关重要。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/ecd1/10015800/a281a8b15874/txad007_fig3.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/ecd1/10015800/52a9bd7f8b7d/txad007_fig1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/ecd1/10015800/fcd5a8424de7/txad007_fig2.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/ecd1/10015800/a281a8b15874/txad007_fig3.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/ecd1/10015800/52a9bd7f8b7d/txad007_fig1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/ecd1/10015800/fcd5a8424de7/txad007_fig2.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/ecd1/10015800/a281a8b15874/txad007_fig3.jpg

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