通过过氧化物酶体表面展示获取乙酰辅酶A。
Gaining access to acetyl-CoA by peroxisomal surface display.
作者信息
Perrot Thomas, Besseau Sébastien, Papon Nicolas, Courdavault Vincent
机构信息
Biomolécules et Biotechnologies Végétales, BBV, EA2106, Université de Tours, Tours, France.
Univ Angers, Univ Brest, IRF, SFR ICAT, F-49000, Angers, France.
出版信息
Synth Syst Biotechnol. 2023 Mar 6;8(2):224-226. doi: 10.1016/j.synbio.2023.02.003. eCollection 2023 Jun.
Synthetic biology is constantly making progress for producing compounds on demand. Recently, Yocum and collaborators have developed an outstanding approach based on the anchoring of biosynthetic enzymes to the peroxisomal membrane. This allowed access to an untapped resource of acetyl-CoA and stimulated the synthesis of a valuable polyketide.
合成生物学在按需生产化合物方面不断取得进展。最近，约库姆及其合作者基于将生物合成酶锚定到过氧化物酶体膜上开发了一种出色的方法。这使得能够利用未开发的乙酰辅酶A资源，并刺激了一种有价值的聚酮化合物的合成。
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