Kronborg O, Hage E, Adamsen S, Deichgraeber E
Scand J Gastroenterol. 1983 Nov;18(8):1089-93. doi: 10.3109/00365528309181846.
To investigate the effect of follow-up study after colorectal polypectomy, 156 patients with symptomatic stalked adenomas with light to severe dysplasia were allocated at random to colorectal examination every 6 (A) and 24 (B) months after colonoscopic polypectomy. No high-risk group could be identified. Twenty-one of the 23 new polyps were located above the rectum, but 15 could have been removed during examination with the flexible sigmoidoscope. The risk of new adenomas was similar at all 6-month examinations, during the first 4 years of the study. A small carcinoma (Dukes A) was found at 24 months in group B. A fatal colonic perforation was seen in group A after seven previous colonoscopies without complications. The new polyps caused no symptoms other than minimal bleeding in some of the patients, and because increasing the rate of colonoscopies increases risk of complications, it was considered justified to prolong the intervals to 24 and 48 months, at random.
为研究结直肠息肉切除术后随访的效果，将156例有轻至重度发育异常的有蒂症状性腺瘤患者随机分为两组，在结肠镜息肉切除术后分别每6个月（A组）和24个月（B组）进行结直肠检查。未识别出高危组。23个新息肉中有21个位于直肠上方，但其中15个可在乙状结肠镜检查时切除。在研究的前4年，所有6个月检查时新腺瘤的风险相似。B组在24个月时发现1例小癌（Dukes A期）。A组在先前7次结肠镜检查无并发症后出现致命性结肠穿孔。新息肉除在部分患者中引起轻微出血外无其他症状，由于增加结肠镜检查频率会增加并发症风险，因此认为将检查间隔随机延长至24个月和48个月是合理的。
