From the Eighth Department of Surgery (Xu), The Shanghai Municipal Hospital of Traditional Chinese Medicine; from Urology Surgery (Peng), Yueyang Hospital of Integrated Traditional Chinese and Western Medicine; and from the Shanghai Research Institute of Qigong (Chen), Taiji Health Center, Shanghai University of Traditional Chinese Medicine, Shanghai, China.
Saudi Med J. 2023 Mar;44(3):253-259. doi: 10.15537/smj.2023.44.3.20220676.
To examined the efficacy and safety of Peng's Shengjing recipe in treating asthenospermia with deficiency and failure of kidney yang. The traditional Chinese medicine (TCM) Peng's Shengjing recipe might have benefits in treating male asthenospermia.
This randomized, positive drug-controlled, single-blind pilot study enrolled outpatients from the Third Department of Traditional Chinese Medicine Surgery, Shanghai University of Traditional Chinese Medicine, Shanghai, China, between April 2020 and September 2020. A total of 99 participants were randomized to Shengjing recipe (n=50) and Xuanju capsule (n=49). They were treated for 12 weeks. The primary endpoint was routine semen examinations, including the percentage of sperm motility rated grade A, A+B, and A+B+C, and the clinical effective rate. The secondary endpoints were the levels of gonadotropins.
The A grade sperms (18.9% versus [vs.] 13.9%, =0.030) and A+B grade sperms (42.9% vs. 32.7%, <0.001) were higher in the Shengjing recipe group than the Xuanju capsule group. The effective rates were 68% and 53.1% in the Shengjing recipe and Xuanju capsule groups (=0.128). No safety signals were observed.
Peng's Shengjing recipe improves the quality of sperms and is effective in treating clinical asthenospermia of deficiency of kidney yang. The treatment was well tolerated, without obvious hepatorenal toxicity..
观察补肾生精方治疗肾阳虚衰型弱精子症的临床疗效及安全性。补肾生精方可能对男性弱精子症具有治疗作用。
本研究为随机、阳性药物对照、单盲的临床试验，纳入 2020 年 4 月至 9 月上海中医药大学附属曙光医院中医外科门诊就诊的弱精子症患者 99 例，按随机数字表法分为补肾生精方组（50 例）和玄驹胶囊组（49 例），分别给予补肾生精方和玄驹胶囊治疗，疗程 12 周。主要结局指标为精液常规检查，包括精子活动率 A 级、A+B 级和 A+B+C 级的比例，以及临床有效率。次要结局指标为血清生殖激素水平。
补肾生精方组精子 A 级（18.9%比 13.9%，=0.030）和 A+B 级（42.9%比 32.7%，<0.001）比例高于玄驹胶囊组，临床有效率分别为 68%和 53.1%（=0.128）。两组均未发生与药物相关的不良反应。
补肾生精方可提高肾阳虚衰型弱精子症患者的精子质量，改善患者的临床症状，疗效确切，且安全性良好。
