Department of Nutrition, Exercise and Sports, University of Copenhagen, Frederiksberg, Denmark.
APC Microbiome Ireland, Teagasc Moorepark Food Research Centre, Fermoy, Co. Cork, Ireland.
Gut Microbes. 2023 Jan-Dec;15(1):2192151. doi: 10.1080/19490976.2023.2192151.
The development of infant gut microbiome is a pivotal process affecting the ecology and function of the microbiome, as well as host health. While the establishment of the infant microbiome has been of interest for decades, the focus on gut microbial metabolism and the resulting small molecules (metabolites) has been rather limited. However, technological and computational advances are now enabling researchers to profile the plethora of metabolites in the infant gut, allowing for improved understanding of how gut microbial-derived metabolites drive microbiome community structuring and host-microbial interactions. Here, we review the current knowledge on development of the infant gut microbiota and metabolism within the first year of life, and discuss how these microbial metabolites are key for enhancing our basic understanding of interactions during the early life developmental window.
婴儿肠道微生物组的发展是一个关键过程，影响微生物组的生态和功能以及宿主健康。虽然婴儿微生物组的建立已经引起了数十年的关注，但对肠道微生物代谢及其产生的小分子（代谢物）的关注却相当有限。然而，技术和计算的进步现在使研究人员能够分析婴儿肠道中的大量代谢物，从而更好地了解肠道微生物衍生的代谢物如何驱动微生物组群落结构和宿主-微生物相互作用。在这里，我们回顾了生命最初一年婴儿肠道微生物组和代谢的发展的现有知识，并讨论了这些微生物代谢物如何成为增强我们对早期生命发育窗口期间相互作用的基本理解的关键。
