白尾鹿血清能杀死莱姆病螺旋体，
White-Tailed Deer Serum Kills the Lyme Disease Spirochete, .
机构信息
Laboratory of Medical Zoology, Department of Microbiology, University of Massachusetts, Amherst, Massachusetts, USA.
Massachusetts Division of Fisheries and Wildlife, Westborough, Massachusetts, USA.
出版信息
Vector Borne Zoonotic Dis. 2023 May;23(5):303-305. doi: 10.1089/vbz.2022.0095. Epub 2023 Mar 21.
Abstract
is a human pathogen vectored by ticks and maintained in nature by a suite of competent vertebrate reservoirs. White-tailed deer (WTD) are considered to be noncompetent reservoirs for . Sera from other deer species have been found to be borreliacidal, and similar mechanisms could explain the lack of reservoir competence of WTD. Therefore, we determined whether WTD serum can kill Using an serum sensitivity assay and subculturing of spirochetes, we demonstrated that WTD serum effectively kills . The borreliacidal activity of WTD serum likely contributes to the inability of WTD to efficiently harbor and transmit .
摘要
是一种由蜱传播的人类病原体，并由一系列有能力的脊椎动物库在自然界中维持。白尾鹿（WTD）被认为是非能力宿主。已经发现其他鹿种的血清具有杀伯氏疏螺旋体的作用，类似的机制可以解释 WTD 缺乏宿主能力的原因。因此，我们确定 WTD 血清是否可以杀死。我们使用伯氏疏螺旋体血清敏感性测定和螺旋体的亚培养，证明了 WTD 血清可以有效地杀死。WTD 血清的杀伯氏疏螺旋体活性可能有助于 WTD 无法有效地容纳和传播。
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