Department of Global Health and Infection, 12190Brighton and Sussex Medical School, Brighton, UK.
Faculty of Health, 6633University of Plymouth, Plymouth, UK.
J Int Assoc Provid AIDS Care. 2023 Jan-Dec;22:23259582231164241. doi: 10.1177/23259582231164241.
This study aimed to validate and assess a comprehensive set of illness-specific health-related quality of life (HRQL) domains in people living with HIV (PLWH) with cognitive symptoms. One hundred and three HIV patients with cognitive symptoms ( = 93 male, 90.3%) were identified from two UK HIV clinics and complete a series of validated scales measuring seven HRQL domains identified as important to HRQL by PLWH with cognitive impairment. These included: physical functioning, cognition, social connectedness, self-concept, HIV stigma, acceptance of and perceived control over cognitive health, and physical and mental health and wellbeing. Exploratory factor analysis confirmed that domain total scores loaded onto one main factor, representing HRQL. Scale cut-off scores revealed a significant proportion of patients scored outside the normal range on single domains (between 26.2% and 79.6%), and many patients on multiple domains (40.8% on 4 or more domains). We found evidence of poor HRQL across domains in the majority of PLWH with cognitive symptoms and identified domains driving these experiences. This provides targets for intervention development and clinical action to maintain or improve HRQL in PLWH with cognitive symptoms or impairment.
本研究旨在验证和评估一套针对有认知症状的 HIV 感染者（PLWH）的全面疾病特异性健康相关生活质量（HRQL）领域。从英国的两家 HIV 诊所中确定了 103 名有认知症状的 HIV 患者（ = 93 名男性，90.3%），他们完成了一系列经过验证的量表，这些量表衡量了对认知障碍的 PLWH 来说重要的七个 HRQL 领域。这些领域包括：身体机能、认知、社交联系、自我概念、HIV 污名、对认知健康的接受和感知控制，以及身心健康和幸福感。探索性因素分析证实，领域总分加载到一个主要因素上，代表 HRQL。量表的临界值得分表明，许多患者在多个领域（40.8%的患者在 4 个或更多领域）的单一领域得分超出了正常范围（26.2%到 79.6%之间）。我们发现，大多数有认知症状的 PLWH 的 HRQL 在大多数领域都较差，并确定了驱动这些体验的领域。这为干预措施的发展和临床行动提供了目标，以维持或改善有认知症状或认知障碍的 PLWH 的 HRQL。
