男性足球运动员与健康非运动员对照人群中尿8-羟基-2'-脱氧鸟苷水平、F-异前列腺素水平与饮食炎症及抗氧化指标之间的关联。
Association between urinary levels of 8-hydroxy-2-deoxyguanosine and F-isoprostane in male football players and healthy non-athlete controls with dietary inflammatory and antioxidant indices.
作者信息
Zare Mahsa, Shateri Zainab, Nouri Mehran, Sarbakhsh Parvin, Eftekhari Mohammad Hasan, Pourghassem Gargari Bahram
机构信息
Student Research Committee, Faculty of Nutrition and Food Science, Tabriz University of Medical Sciences, Tabriz, Iran.
Student Research Committee, Ahvaz Jundishapour University of Medical Science, Ahvaz, Iran.
出版信息
Front Nutr. 2023 Jan 24;9:1101532. doi: 10.3389/fnut.2022.1101532. eCollection 2022.
PURPOSE
The relationship between the inflammatory and antioxidant potential of an athlete's diet and their oxidative biomarkers is an important area of investigation. Therefore, this study aimed to assess the excretion of 8-hydroxy-2-deoxyguanosine (8-OHdG) and F-isoprostane (F-IP) in the urine of male football players and healthy non-athlete controls. This study also aimed to examine the associations among the dietary inflammatory index (DII), the dietary total antioxidant capacity (DTAC), and the dietary phytochemical index (PI) with 8-OHdG and F-IP.
METHODS
In this descriptive-analytical study, 45 male football players and 45 healthy non-athletes, who were individually matched based on age and body mass index (BMI), were recruited from Shiraz City, Iran. Fasted urine samples were analyzed for 8-OHdG and F-IP levels. Anthropometric measurements were performed, and body composition was assessed using a body composition analyzer. A valid food frequency questionnaire (FFQ) was used to calculate DII, DTAC, and PI scores. Data analysis was conducted using a generalized estimating equation (GEE) model.
RESULTS
We found that 8-OHdG (β = -6.96), F-IP (β = -82.58), and DII (β = -2.06) were significantly lower, while DTAC (β = 2.37) and PI (β = 0.084) were significantly higher in the football player group compared with the non-athlete group ( < 0.001 for all variables). In all participants, dietary indices were significantly associated with oxidative biomarkers. DII was positively associated with 8-OHdG (β = 2.25; < 0.001) and F-IP (β = 38.34; < 0.001). Furthermore, negative associations between DTAC (β = -1.42; < 0.001) and PI (β = -35.37; < 0.001) with 8-OHdG were found. Moreover, DTAC (β = -17.34; < 0.001) and PI (β = -428.11; = 0.003) were negatively associated with F-IP.
CONCLUSION
The results of this study highlighted the importance of a healthy diet in reducing oxidative stress among football athletes. The levels of urinary biomarkers for DNA and lipid oxidation were found to be lower in football players compared to non-athletes. This suggests that following an anti-inflammatory and antioxidant-rich diet may help reduce oxidative stress in these individuals.
目的
运动员饮食的炎症和抗氧化潜力与其氧化生物标志物之间的关系是一个重要的研究领域。因此，本研究旨在评估男性足球运动员和健康非运动员对照组尿液中8-羟基-2-脱氧鸟苷（8-OHdG）和F-异前列腺素（F-IP）的排泄情况。本研究还旨在探讨饮食炎症指数（DII）、饮食总抗氧化能力（DTAC）和饮食植物化学指数（PI）与8-OHdG和F-IP之间的关联。
方法
在这项描述性分析研究中，从伊朗设拉子市招募了45名男性足球运动员和45名健康非运动员，他们根据年龄和体重指数（BMI）进行了个体匹配。对空腹尿液样本进行8-OHdG和F-IP水平分析。进行人体测量，并使用身体成分分析仪评估身体成分。使用有效的食物频率问卷（FFQ）计算DII、DTAC和PI得分。使用广义估计方程（GEE）模型进行数据分析。
结果
我们发现，与非运动员组相比，足球运动员组的8-OHdG（β = -6.96）、F-IP（β = -82.58）和DII（β = -2.06）显著较低，而DTAC（β = 2.37）和PI（β = 0.084）显著较高（所有变量P < 0.001）。在所有参与者中，饮食指数与氧化生物标志物显著相关。DII与8-OHdG（β = 2.25；P < 0.001）和F-IP（β = 38.34；P < 0.001）呈正相关。此外，发现DTAC（β = -1.42；P < 0.001）和PI（β = -35.37；P < 0.001）与8-OHdG呈负相关。此外，DTAC（β = -17.34；P < 0.001）和PI（β = -428.11；P = 0.003）与F-IP呈负相关。
结论
本研究结果强调了健康饮食在减少足球运动员氧化应激方面的重要性。与非运动员相比，足球运动员的DNA和脂质氧化尿生物标志物水平较低。这表明遵循富含抗炎和抗氧化剂的饮食可能有助于降低这些个体的氧化应激。
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