超声角膜测厚仪、角膜地形图、谱域光学相干断层扫描和非接触镜面反射显微镜测量的中央角膜厚度比较。
Comparison of central corneal thickness measured by ultrasound pachymetry, corneal topography, spectral domain- optical coherence tomography, and non-contact specular microscopy.
机构信息
Department of Ophthalmology, University of Health Sciences, Yuksek Ihtisas Training and Research Hospital, Bursa, Türkiye.
Department of Biostatistics, Bursa Uludag University, Faculty of Medicine, Bursa, Türkiye.
出版信息
Photodiagnosis Photodyn Ther. 2023 Jun;42:103527. doi: 10.1016/j.pdpdt.2023.103527. Epub 2023 Mar 24.
BACKGROUND
This study aims to investigate the compatibility of central corneal thickness (CCT) measurements obtained with spectral-domain optical coherence tomography (SD-OCT), Scheimpflug-Placido-based corneal topography (CT), non-contact specular microscopy (NCSM), and ultrasonic pachymetry (UP). These four corneal measurement techniques have not been compared in a single study on these many subjects.
METHODS
CCT was measured in 185 eyes of 185 volunteers with each of the four devices by a single observer. CCTs from Optovue® iVue SD-OCT, Sirius corneal topography, NonconRobo NCSM, and Accutom UP devices were recorded. Compatibility between devices was evaluated with intraclass correlation coefficient (ICC) and Bland-Altman plots. Pairwise comparisons were performed using the Bonferroni test. Measurement differences between devices were analyzed with the Pearson correlation coefficient.
RESULTS
Of the 185 volunteers, 103 were men, and 82 were women. Their mean age was 48.55 ± 16.6 (18-70) years. Mean CCT values measured by UP, CT, OCT, and NCSM were 546.77 ± 39.2, 535.29 ± 39.2, 526.49 ± 39.05, 505.15 ± 46.1 µm, respectively. Statistically significant differences were found between the mean CCT values obtained from the paired devices (p <0.001). The highest difference between pairs was found between UP and NCSM (43.63 ± 1.8 µm; CI 38.74 to 48.5 µm; p <0.001), while the lowest difference was found between OCT and CT (7.3 ± 1.5 µm; 95%CI 3.1 to 11.6 µm; p <0.001). In pairwise comparisons of four devices, the highest ICC value was between UP and CT (ICC: 0.899, 95%CI 0.759-0.947; p <0.001).
CONCLUSION
Despite the high correlation between measurements obtained from different methods, notable differences in CCT values exist, rendering devices non-interchangeable. Therefore, alternative brands of the same device may yield different outcomes.
背景
本研究旨在探讨使用谱域光学相干断层扫描（SD-OCT）、Scheimpflug-Placido 角膜地形图（CT）、非接触式共焦显微镜（NCSM）和超声角膜测厚仪（UP）获得的中央角膜厚度（CCT）测量值的兼容性。这些四种角膜测量技术尚未在对如此多的受试者进行的单一研究中进行比较。
方法
由一名观察者对 185 名志愿者的 185 只眼分别使用这四种设备进行 CCT 测量。记录 Optovue® iVue SD-OCT、Sirius 角膜地形图、NonconRobo NCSM 和 Accutom UP 设备的 CCT 值。使用组内相关系数（ICC）和 Bland-Altman 图评估设备之间的兼容性。使用 Bonferroni 检验进行设备间的两两比较。使用 Pearson 相关系数分析设备间的测量差异。
结果
在 185 名志愿者中，男性 103 名，女性 82 名。他们的平均年龄为 48.55 ± 16.6（18-70）岁。UP、CT、OCT 和 NCSM 测量的平均 CCT 值分别为 546.77 ± 39.2、535.29 ± 39.2、526.49 ± 39.05 和 505.15 ± 46.1 µm。配对设备获得的平均 CCT 值之间存在显著差异（p<0.001）。配对设备之间发现的最大差异为 UP 和 NCSM 之间（43.63 ± 1.8 µm；CI 38.74 至 48.5 µm；p<0.001），而最小差异为 OCT 和 CT 之间（7.3 ± 1.5 µm；95%CI 3.1 至 11.6 µm；p<0.001）。在四种设备的两两比较中，UP 和 CT 之间的 ICC 值最高（ICC：0.899，95%CI 0.759-0.947；p<0.001）。
结论
尽管不同方法获得的测量值之间具有高度相关性，但 CCT 值存在明显差异，使得设备不可互换。因此，同一设备的替代品牌可能会产生不同的结果。
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