Borelli Wyllians Vendramini, Formoso Carolina Rodrigues, Bieger Andrei, Ferreira Pamela Lukasewicz, Zimmer Eduardo R, Pascoal Tharick Ali, Chaves Marcia Lorena Fagundes, Castilhos Raphael Machado
Pharmacology and Therapeutics Research Program Universidade Federal do Rio Grande do Sul (UFRGS) Porto Alegre Brazil.
Cognitive and Behavioral Neurology Center Neurology Service Hospital de Clínicas de Porto Alegre (HCPA) Porto Alegre Brazil.
Alzheimers Dement (Amst). 2023 Mar 22;15(1):e12408. doi: 10.1002/dad2.12408. eCollection 2023 Jan-Mar.
Risk factors for dementia have distinct frequency and impact in relation to race. Our aim was to identify differences in modifiable risk factors of dementia related to races and estimate their population attributable fraction (PAF).
An epidemiological cohort was used to estimate the prevalence of 10 modifiable risk factors for dementia among five races-White, Black, Brown, Asian, and Indigenous. Sample weighting was used to estimate the prevalence and PAF of each risk factor in each race.
A total of 9070 individuals were included. Overall adjusted PAF was the lowest in Indigenous (38.9%), and Asian individuals (41.2%). Race-related prevalence of individual risk factors was widely variable in our population, but hearing loss was the most important contributor to the overall PAF in all races.
Public policies aiming to reduce preventable risk factors for dementia should take into consideration the race of the target populations.
Preventable risk factors for dementia vary according to race.Hearing loss presented the highest prevalence among all races studied.Indigenous and Asian individuals presented the lowest population attributable fractions.Black and Brown individuals were more vulnerable to social determinants.
痴呆症的风险因素在种族方面具有不同的频率和影响。我们的目的是确定与种族相关的痴呆症可改变风险因素的差异，并估计其人群归因分数（PAF）。
采用一项流行病学队列研究来估计白人、黑人、棕色人种、亚洲人和原住民这五个种族中10种痴呆症可改变风险因素的患病率。样本加权用于估计每个种族中每种风险因素的患病率和PAF。
共纳入9070名个体。总体调整后的PAF在原住民（38.9%）和亚洲个体（41.2%）中最低。在我们的人群中，个体风险因素与种族相关的患病率差异很大，但听力损失是所有种族总体PAF的最重要贡献因素。
旨在减少痴呆症可预防风险因素的公共政策应考虑目标人群的种族。
痴呆症的可预防风险因素因种族而异。在所研究的所有种族中，听力损失的患病率最高。原住民和亚洲个体的人群归因分数最低。黑人和棕色人种个体更容易受到社会决定因素的影响。
