Data and Analysis for Social Care and Health, Office for National Statistics, Newport, NP10 8XG, UK.
Department of Medical Statistics, London School of Hygiene and Tropical Medicine, London, UK.
Nat Commun. 2023 Mar 27;14(1):1541. doi: 10.1038/s41467-023-36494-0.
Several studies have reported associations between COVID-19 vaccination and risk of cardiac diseases, especially in young people; the impact on mortality, however, remains unclear. We use national, linked electronic health data in England to assess the impact of COVID-19 vaccination and positive SARS-CoV-2 tests on the risk of cardiac and all-cause mortality in young people (12 to 29 years) using a self-controlled case series design. Here, we show there is no significant increase in cardiac or all-cause mortality in the 12 weeks following COVID-19 vaccination compared to more than 12 weeks after any dose. However, we find an increase in cardiac death in women after a first dose of non mRNA vaccines. A positive SARS-CoV-2 test is associated with increased cardiac and all-cause mortality among people vaccinated or unvaccinated at time of testing.
多项研究报告了 COVID-19 疫苗接种与心脏病风险之间的关联，尤其是在年轻人中；然而，其对死亡率的影响尚不清楚。我们使用英国全国性的、关联的电子健康数据，采用自身对照病例系列设计，评估 COVID-19 疫苗接种和 SARS-CoV-2 检测阳性对年轻人（12 至 29 岁）心脏和全因死亡率的影响。在这里，我们表明，与接种任何剂量疫苗后 12 周以上相比，COVID-19 疫苗接种后 12 周内心脏或全因死亡率没有显著增加。然而，我们发现，在接种非 mRNA 疫苗的第一针后，女性的心脏死亡人数有所增加。在进行检测时接种或未接种疫苗的人中，SARS-CoV-2 检测阳性与心脏和全因死亡率增加相关。
