Faculty of Medical Sciences, Neuroscience Research Centre, Lebanese University, Beirut, Lebanon.
Pierre and Marie Curie Campus, Sorbonne University, Paris, France.
Alzheimers Res Ther. 2023 Mar 27;15(1):65. doi: 10.1186/s13195-023-01214-9.
The use of music interventions as a non-pharmacological therapy to improve cognitive and behavioral symptoms in Alzheimer's disease (AD) patients has gained popularity in recent years, but the evidence for their effectiveness remains inconsistent.
To summarize the evidence of the effect of music therapy (alone or in combination with pharmacological therapies) on cognitive functions in AD patients compared to those without the intervention.
A systematic literature search was performed in PubMed, Cochrane library, and HINARI for papers published from 1 January 2012 to 25 June 2022. All randomized controlled trials that compared music therapy with standard care or other non-musical intervention and evaluation of cognitive functions are included. Cognitive outcomes included: global cognition, memory, language, speed of information processing, verbal fluency, and attention. Quality assessment and narrative synthesis of the studies were performed.
A total of 8 studies out of 144 met the inclusion criteria (689 participants, mean age range 60.47-87.1). Of the total studies, 4 were conducted in Europe (2 in France, 2 in Spain), 3 in Asia (2 in China, 1 in Japan), and 1 in the USA. Quality assessment of the retrieved studies revealed that 6 out of 8 studies were of high quality. The results showed that compared to different control groups, there is an improvement in cognitive functions after music therapy application. A greater effect was shown when patients are involved in the music making when using active music intervention (AMI).
The results of this review highlight the potential benefits of music therapy as a complementary treatment option for individuals with AD and the importance of continued investigation in this field. More research is needed to fully understand the effects of music therapy, to determine the optimal intervention strategy, and to assess the long-term effects of music therapy on cognitive functions.
近年来，音乐干预作为一种非药物疗法，用于改善阿尔茨海默病（AD）患者的认知和行为症状，已越来越受到关注，但其实效证据仍不一致。
总结音乐治疗（单独或与药物治疗联合使用）对 AD 患者认知功能的影响证据，与未进行干预的患者进行比较。
对 2012 年 1 月 1 日至 2022 年 6 月 25 日期间在 PubMed、Cochrane 图书馆和 HINARI 上发表的文献进行系统的文献检索。纳入比较音乐治疗与标准护理或其他非音乐干预，并评估认知功能的随机对照试验。认知结局包括：总体认知、记忆、语言、信息处理速度、言语流畅性和注意力。对研究进行质量评估和叙述性综合分析。
从 144 篇文献中共有 8 篇研究符合纳入标准（共纳入 689 名参与者，平均年龄范围 60.47-87.1 岁）。在所有研究中，4 项研究在欧洲进行（法国 2 项，西班牙 2 项），3 项在亚洲进行（中国 2 项，日本 1 项），1 项在美国进行。对检索到的研究进行质量评估后发现，8 篇研究中有 6 篇质量较高。结果表明，与不同对照组相比，音乐治疗应用后认知功能有所改善。当患者参与音乐创作时（主动音乐干预），效果更为显著。
本综述结果强调了音乐治疗作为 AD 患者辅助治疗选择的潜在益处，以及在该领域继续开展研究的重要性。需要进一步研究以充分了解音乐治疗的效果，确定最佳干预策略，并评估音乐治疗对认知功能的长期影响。
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