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机器人辅助腹腔镜根治性前列腺切除术后膀胱尿道吻合口处Hem-o-Lok夹移位的结局:单中心经验

Outcomes of Hem-o-Lok clip migration at vesico-urethral anastomotic site post-robotic-assisted laparoscopic radical prostatectomy: a single centre experience.

作者信息

Singh Abhishek, Sharma Rohan, Agrawal Anshul, Surwase Pavan Prabhakar, Patil Abhijit, Batra Rohan, Ganpule Arvind, Sabnis Ravindra, Desai Mahesh

机构信息

Department of Urology, Muljibhai Patel Urological Hospital, Nadiad, India.

出版信息

Int Urol Nephrol. 2023 Jun;55(6):1467-1475. doi: 10.1007/s11255-023-03554-9. Epub 2023 Mar 28.

DOI:10.1007/s11255-023-03554-9
PMID:36976419
Abstract

BACKGROUND

Robotic-assisted laparoscopic prostatectomy (RALP) is the most preferred intervention for the management of prostatic malignancy worldwide. Hem-o-Lok clips (HOLC) are widely used for haemostasis and lateral pedicle ligation. These clips are prone to migrate and lodge at the anastomotic junction as well as inside the bladder causing lower urinary tract symptoms (LUTS) secondary to bladder neck contracture (BNC) or bladder calculi. The objective of this study is to describe the incidence, clinical presentation, management, and outcome of HOLC migration.

METHODOLOGY

Retrospective analysis of the database of Post RALP patients who developed LUTS secondary to HOLC migration was done. Cystoscopy findings, number of procedures required, number of HOLC removed intra-operatively, and follow-up of the patients was reviewed.

RESULTS

The incidence of HOLC migration requiring intervention was 1.78% (9/505). The mean age of the patient, BMI, Pre-operative Serum PSA were 62.8 years, 27.8 kg/m, and 9.8 ng/mL, respectively. The mean duration of appearance of symptoms due to HOLC migration was 9 months. Two patients presented with Haematuria and 7 presented with LUTS. Seven patients required a single intervention while 2 required up to 6 procedures for recurrent symptoms secondary to recurrent HOLC migration.

CONCLUSION

HOLC use in RALP may present with migration and associated complications. HOLC migration is associated with severe BNC and may require multiple endoscopic interventions. Severe dysuria and LUTS not responding to medical management should be treated using an algorithmic approach and there should be a low threshold for performing cystoscopy and intervention in these cases to improve outcomes.

摘要

背景

机器人辅助腹腔镜前列腺切除术(RALP)是全球治疗前列腺恶性肿瘤最常用的干预手段。Hem-o-Lok夹(HOLC)广泛用于止血和侧蒂结扎。这些夹子容易迁移并滞留在吻合口处以及膀胱内,导致继发于膀胱颈挛缩(BNC)或膀胱结石的下尿路症状(LUTS)。本研究的目的是描述HOLC迁移的发生率、临床表现、处理方法及结果。

方法

对因HOLC迁移继发LUTS的RALP术后患者数据库进行回顾性分析。回顾膀胱镜检查结果、所需手术次数、术中取出的HOLC数量以及患者的随访情况。

结果

需要干预的HOLC迁移发生率为1.78%(9/505)。患者的平均年龄、体重指数、术前血清前列腺特异抗原(PSA)分别为62.8岁、27.8kg/m²和9.8ng/mL。HOLC迁移导致症状出现的平均时间为9个月。2例患者出现血尿,7例出现LUTS。7例患者需要单次干预,2例因HOLC反复迁移导致症状复发需要多达6次手术。

结论

RALP中使用HOLC可能会出现迁移及相关并发症。HOLC迁移与严重的BNC相关,可能需要多次内镜干预。对于药物治疗无效的严重排尿困难和LUTS,应采用算法化方法进行治疗,对于这些病例,进行膀胱镜检查和干预的阈值应较低,以改善治疗效果。

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Urol Int. 2019;102(4):495-498. doi: 10.1159/000490857. Epub 2018 Oct 19.
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Bladder neck contracture-incidence and management following contemporary robot assisted radical prostatectomy technique.膀胱颈挛缩:当代机器人辅助根治性前列腺切除术技术后的发生率和处理。
Prostate Int. 2014 Mar;2(1):12-8. doi: 10.12954/PI.13034. Epub 2014 Mar 30.
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BMC Urol. 2014 Feb 20;14:21. doi: 10.1186/1471-2490-14-21.
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