他汀类药物对嚼槟榔者口腔鳞状细胞癌发病率的影响。

The effect of statin medication on the incidence of oral squamous cell carcinoma among betel-nut chewers.

机构信息

Department of Otorhinolaryngology, Lo-Hsu Medical Foundation, Lotung Poh-Ai Hospital, Yilan, Taiwan.

Graduate Institute of Business Administration, College of Management, Fu Jen Catholic University, Taipei, Taiwan.

出版信息

Head Neck. 2023 Jun;45(6):1455-1467. doi: 10.1002/hed.27358. Epub 2023 Mar 28.

DOI:10.1002/hed.27358

PMID:36978212

Abstract

BACKGROUND

This study examines the relationship between statin use and oral cancer squamous cell carcinoma (OCSCC) risk in a cohort of 47 942 betel nut chewers.

METHODS

The study used individual 1:1 matching and propensity score matching to compare statin users and nonusers.

RESULTS

The incidence rate of OCSCC was significantly lower in statin users compared to nonusers (17.12 vs. 26.75 per 10 000 person-years), yielding an incidence rate ratio of 0.64. After adjusting for confounders, statin use was associated with a reduced risk of OCSCC (adjusted hazard ratio: 0.61; 95% confidence interval: 0.52-0.71). A dose-response relationship was observed, with a significant reduction in OCSCC incidence when the cumulative defined daily dose of statin use was equal to or greater than Q3. The risk of OCSCC was lower among users of both hydrophilic and lipophilic statins.

CONCLUSION

This study provides evidence that statin use is associated with a reduced risk of OCSCC in betel nut chewers.

摘要

背景

本研究在 47942 名槟榔咀嚼者队列中考察了他汀类药物使用与口腔癌鳞状细胞癌（OCSCC）风险之间的关系。

方法

该研究采用个体 1:1 匹配和倾向评分匹配来比较他汀类药物使用者和非使用者。

结果

与非使用者相比，他汀类药物使用者的 OCSCC 发病率明显较低（17.12 比 26.75/10000 人年），发病率比为 0.64。在校正混杂因素后，他汀类药物使用与 OCSCC 风险降低相关（调整后的危害比：0.61；95%置信区间：0.52-0.71）。观察到剂量-反应关系，当他汀类药物使用的累积规定日剂量等于或大于 Q3 时，OCSCC 的发病率显著降低。亲水性和疏水性他汀类药物使用者的 OCSCC 风险均较低。