槟郎咀嚼者中他汀类药物的使用及其与食管鳞癌风险降低的关系。
Statin use and its association with decreased risk of esophageal squamous cell carcinoma in betel nut chewers.
机构信息
Liver Research Center, Department of Gastroenterology and Hepatology, Keelung Chang Gung Memorial Hospital, Keelung, Taiwan.
Community Medicine Research Center, Keelung Chang Gung Memorial Hospital, Keelung, Taiwan.
出版信息
Thorac Cancer. 2023 Aug;14(23):2241-2250. doi: 10.1111/1759-7714.15009. Epub 2023 Jul 3.
BACKGROUND
Betel nut chewing involves the chewing of areca nuts or betel quid (areca nuts wrapped in betel leaves), which is associated with an increased risk of esophageal squamous cell carcinoma (ESCC). Statins have anticancer properties. We investigated the association between statin use and ESCC risk in betel nut chewers.
METHODS
The study included 105 387 betel nut chewers matched statin users and nonusers. Statin use was defined as the use of ≥28 cumulative defined daily doses (cDDDs) of statin. The primary outcome was incidence of ESCC.
RESULTS
The incidence rate of ESCC was significantly lower in statin users than in nonusers (2.03 vs. 3.02 per 100 000 person-years). Statin users had a lower incidence rate ratio of 0.66 for ESCC (95% confidence interval [CI]: 0.43-0.85) relative to nonusers. After potential confounders were adjusted for, statin use was determined to be associated with a reduced risk of ESCC (adjusted hazard ratio [aHR], 0.68; 95% CI: 0.51-0.91). A dose-response relationship was observed between statin use and ESCC risk; the aHRs for statin use at 28-182 cDDDs, 183-488 cDDDs, 489-1043 cDDDs, and > 1043 cDDDs were 0.92, 0.89, 0.66, and 0.64, respectively.
CONCLUSION
Statin use was revealed to be associated with a reduced risk of ESCC in betel nut chewers.
背景
咀嚼槟榔涉及食用槟榔果或槟榔块（槟榔果包裹在槟榔叶中），这与食管鳞状细胞癌（ESCC）的风险增加有关。他汀类药物具有抗癌特性。我们研究了他汀类药物使用与嚼槟榔者 ESCC 风险之间的关系。
方法
这项研究纳入了 105387 名嚼槟榔者，匹配了他汀类药物使用者和非使用者。他汀类药物使用的定义为使用了≥28 个累积定义日剂量（cDDD）的他汀类药物。主要结局是 ESCC 的发病率。
结果
与非使用者相比，他汀类药物使用者的 ESCC 发病率明显较低（每 10 万人年 2.03 比 3.02）。他汀类药物使用者的 ESCC 发生率比值比为 0.66（95%置信区间：0.43-0.85）。在调整了潜在混杂因素后，发现他汀类药物的使用与 ESCC 风险降低相关（调整后的危险比[aHR]，0.68；95%置信区间：0.51-0.91）。他汀类药物的使用与 ESCC 风险之间存在剂量-反应关系；他汀类药物使用 28-182 cDDD、183-488 cDDD、489-1043 cDDD 和>1043 cDDD 的 aHR 分别为 0.92、0.89、0.66 和 0.64。
结论
在嚼槟榔者中，他汀类药物的使用与 ESCC 风险降低有关。
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