脑内黏附机制的物理化学原理。

Department of Neurobiology, Maj Institute of Pharmacology, Polish Academy of Sciences, Smętna 12, 31-343 Kraków, Poland.

Int J Mol Sci. 2023 Mar 7;24(6):5070. doi: 10.3390/ijms24065070.

The brain functions through neuronal circuits and networks that are synaptically connected. This type of connection can exist due to physical forces that interact to stabilize local contacts in the brain. Adhesion is a fundamental physical phenomenon that allows different layers, phases, and tissues to connect. Similarly, synaptic connections are stabilized by specialized adhesion proteins. This review discusses the basic physical and chemical properties of adhesion. Cell adhesion molecules (CAMs) such as cadherins, integrins, selectins, and immunoglobulin family of cell adhesion molecules (IgSF) will be discussed, and their role in physiological and pathological brain function. Finally, the role of CAMs at the synapse will be described. In addition, methods for studying adhesion in the brain will be presented.

大脑通过神经元回路和网络发挥功能，这些回路和网络通过突触连接。这种连接之所以能够存在，是因为存在相互作用以稳定大脑中局部接触的物理力。黏附是一种基本的物理现象，它允许不同的层、相和组织连接。同样，突触连接通过专门的黏附蛋白稳定。这篇综述讨论了黏附的基本物理和化学特性。将讨论细胞黏附分子（CAM），如钙黏蛋白、整合素、选择素和免疫球蛋白细胞黏附分子（IgSF）家族，以及它们在生理和病理脑功能中的作用。最后，将描述 CAM 在突触中的作用。此外，还将介绍研究大脑中黏附的方法。