Juthi Ajkia Zaman, Li Fenfen, Wang Bo, Alam Md Mofasserul, Talukder Md Eman, Qiu Bensheng
School of Life Science and Medicine, Department of Biochemistry and Molecular Biology, University of Science and Technology of China, Hefei 230027, China.
Center for Biomedical Imaging, University of Science and Technology of China, Hefei 230026, China.
Pharmaceutics. 2023 Mar 2;15(3):816. doi: 10.3390/pharmaceutics15030816.
Super-porous hydrogels are considered a potential drug delivery network for the sedation of gastric mechanisms with retention windows in the abdomen and upper part of the gastrointestinal tract (GIT). In this study, a novel pH-responsive super-porous hybrid hydrogels (SPHHs) was synthesized from pectin, poly 2-hydroxyethyl methacrylate (2HEMA), and N, N methylene-bis-acrylamide (BIS) via the gas-blowing technique, and then loaded with a selected drug (amoxicillin trihydrate, AT) at pH 5 via an aqueous loading method. The drug-loaded SPHHs-AT carrier demonstrated outstanding (in vitro) gastroretentive drug delivery capability. The study attributed excellent swelling and delayed drug release to acidic conditions at pH 1.2. Moreover, in vitro controlled-release drug delivery systems at different pH values, namely, 1.2 (97.99%) and 7.4 (88%), were studied. These exceptional features of SPHHs-improved elasticity, pH responsivity, and high swelling performance-should be investigated for broader drug delivery applications in the future.
超多孔水凝胶被认为是一种潜在的药物递送网络，可用于在腹部和胃肠道（GIT）上部实现具有滞留窗口的胃部机制镇静。在本研究中，通过气体吹塑技术由果胶、聚甲基丙烯酸2-羟乙酯（2HEMA）和N，N-亚甲基双丙烯酰胺（BIS）合成了一种新型pH响应性超多孔混合水凝胶（SPHHs），然后通过水相加载法在pH 5下加载选定药物（三水合阿莫西林，AT）。载药的SPHHs-AT载体表现出出色的（体外）胃滞留药物递送能力。该研究将优异的溶胀和药物缓释归因于pH 1.2的酸性条件。此外，还研究了在不同pH值（即1.2（97.99%）和7.4（88%））下的体外控释药物递送系统。SPHHs的这些卓越特性——改善的弹性、pH响应性和高溶胀性能——未来应针对更广泛的药物递送应用进行研究。
