State Key Laboratory of Biochemical Engineering, Institute of Process Engineering, Chinese Academy of Sciences, Beijing 100190, P. R. China.
School of Chemical Engineering, University of Chinese Academy of Sciences, Beijing 100049, P. R. China.
Chem Soc Rev. 2023 Apr 24;52(8):2688-2712. doi: 10.1039/d2cs00675h.
Chromoproteins are a class of delicate natural compounds that elegantly complex photosensitive species with proteins and play a central role in important life processes, such as photosynthesis. Inspired by chromoproteins, researchers integrate simple peptides and photosensitive molecular motifs to generate chromopeptides. Compared with chromoproteins, chromopeptides exhibit a relatively simple molecular structure, flexible and adjustable photophysical properties, and a capability of programmable self-assembly. Chromopeptide self-assembly has attracted great attention as the resultant high-level architectures exhibit an ingenious combination of photofunctions and biofunctions. This review systematically summarizes recent advances in chromopeptide nanoarchitectonics with particular focus on the design strategy, assembly mechanism, and structure-function relationship. Among them, the effect of peptide sequences and the variation in photophysical performance are critically emphasized. On this basis, various applications, including biomedicine and artificial photosynthesis, are discussed together with the future prospects of chromopeptide nanoarchitectonics. This review will provide insights into chromopeptide nanoarchitectonics and corresponding materials with precise designs, flexible nanostructures and versatile functions. In addition, knowledge involving chromopeptide nanoarchitectonics may aid in the development of many other kinds of supramolecular biological materials and bioengineering techniques.
色蛋白是一类精致的天然化合物，它们将光敏物种与蛋白质优雅地结合在一起，在光合作用等重要生命过程中发挥着核心作用。受色蛋白的启发，研究人员将简单的肽和光敏分子基元整合在一起，生成色肽。与色蛋白相比，色肽具有相对简单的分子结构、灵活可调的光物理性质以及可编程自组装的能力。色肽自组装引起了极大的关注，因为所得的高级结构巧妙地结合了光功能和生物功能。本综述系统地总结了色肽纳结构的最新进展，特别关注设计策略、组装机制和结构-功能关系。其中，强调了肽序列的影响和光物理性能的变化。在此基础上，讨论了包括生物医学和人工光合作用在内的各种应用，以及色肽纳结构的未来前景。本综述将为具有精确设计、灵活结构和多功能的色肽纳结构和相应材料提供深入的见解。此外，涉及色肽纳结构的知识可能有助于开发许多其他类型的超分子生物材料和生物工程技术。
