Tsinghua-Peking Center for Life Sciences, School of Medicine, Tsinghua University, Beijing 100084, China.
Institute of Infectious Diseases, Shenzhen Bay Laboratory, Shenzhen 518000, China.
Viruses. 2023 Apr 18;15(4):995. doi: 10.3390/v15040995.
Mpox (previously known as monkeypox) is an infectious viral illness caused by the mpox virus (MPXV), an orthopoxvirus that belongs to the family . The symptoms of mpox in humans are similar to those of smallpox, although the mortality rate is lower. In recent years, the concern over a potential global pandemic has increased due to reports of mpox spreading across Africa and other parts of the world. Prior to this discovery, mpox was a rare zoonotic disease restricted to endemic regions of Western and Central Africa. The sudden emergence of MPXV cases in multiple regions has raised concerns about its natural evolution. This review aims to provide an overview of previously available information about MPXV, including its genome, morphology, hosts and reservoirs, and virus-host interaction and immunology, as well as to perform phylogenetic analysis on available MPXV genomes, with an emphasis on the evolution of the genome in humans as new cases emerge.
猴痘（以前称为猴痘）是一种由猴痘病毒（MPXV）引起的传染性病毒性疾病，猴痘病毒属于正痘病毒科。人类的猴痘症状与天花相似，尽管死亡率较低。近年来，由于有报道称猴痘在非洲和世界其他地区传播，人们对潜在的全球大流行的担忧加剧。在此发现之前，猴痘是一种罕见的人畜共患病，仅限于西非和中非的流行地区。MPXV 病例在多个地区的突然出现引起了人们对其自然进化的关注。本综述旨在提供有关 MPXV 的现有信息概述，包括其基因组、形态、宿主和储存宿主以及病毒-宿主相互作用和免疫学，同时对现有 MPXV 基因组进行系统发育分析，重点关注新病例出现时人类基因组的进化。
